Concept explainers
(a)
Interpretation:
Whether the compound ketoacyl CoA is associated with (1) the β-oxidation pathway, (2) ketogenesis, or (3) both the β-oxidation pathway and ketogenesis has to be identified.
Concept introduction:
Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules.
The β-oxidation is a catabolic process occurring in the body through which, fatty acid molecules are broken down in the mitochondria of the cells to generate energy. The process involves breaking down long fatty acid chains that have been converted to acetyl CoA chains into smaller fatty acetyl CoA chains. The fatty acid chain is broken down until the final acetyl CoA chain cannot be broken down any further. The end products of this
(b)
Interpretation:
Whether the compound acetoacetyl CoA is associated with (1) the β-oxidation pathway, (2) ketogenesis, or (3) both the β-oxidation pathway and ketogenesis has to be identified.
Concept introduction:
Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules. Ketone bodies are generally produced when the amount of acetyl CoA in the body is much larger than the amount of oxaloacetate. This happens due to the carbohydrate-lipid imbalance in the body caused by much smaller intake of food rich in carbohydrates, or inefficient processing of glucose by the body.
β-oxidation is a catabolic process occurring in the body through which, fatty acid molecules are broken down in the mitochondria of the cells to generate energy. The process involves breaking down long fatty acid chains that have been converted to acetyl CoA chains into smaller fatty acetyl CoA chains. The fatty acid chain is broken down until the final acetyl CoA chain cannot be broken down any further. The end products of this metabolic process are acetyl CoA, FADH2 and NADH. These three molecules later enter the Krebs cycle where they are used to produce ATP molecules.
(c)
Interpretation:
Whether the compound acetoacetate is associated with (1) the β-oxidation pathway, (2) ketogenesis, or (3) both the β-oxidation pathway and ketogenesis has to be identified.
Concept introduction:
Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules. Ketone bodies are generally produced when the amount of acetyl CoA in the body is much larger than the amount of oxaloacetate. This happens due to the carbohydrate-lipid imbalance in the body caused by much smaller intake of food rich in carbohydrates, or inefficient processing of glucose by the body.
β-oxidation is a catabolic process occurring in the body through which, fatty acid molecules are broken down in the mitochondria of the cells to generate energy. The process involves breaking down long fatty acid chains that have been converted to acetyl CoA chains into smaller fatty acetyl CoA chains. The fatty acid chain is broken down until the final acetyl CoA chain cannot be broken down any further. The end products of this metabolic process are acetyl CoA, FADH2 and NADH. These three molecules later enter the Krebs cycle where they are used to produce ATP molecules.
(d)
Interpretation:
Whether the compound hydroxyacyl CoA is associated with (1) the β-oxidation pathway, (2) ketogenesis, or (3) both the β-oxidation pathway and ketogenesis has to be identified.
Concept introduction:
Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules. Ketone bodies are generally produced when the amount of acetyl CoA in the body is much larger than the amount of oxaloacetate. This happens due to the carbohydrate-lipid imbalance in the body caused by much smaller intake of food rich in carbohydrates, or inefficient processing of glucose by the body.
β-oxidation is a catabolic process occurring in the body through which, fatty acid molecules are broken down in the mitochondria of the cells to generate energy. The process involves breaking down long fatty acid chains that have been converted to acyl CoA chains into smaller fatty acyl CoA chains. The fatty acid chain is broken down until the final acyl CoA chain cannot be broken down any further. The end products of this metabolic process are acetyl CoA, FADH2 and NADH. These three molecules later enter the Krebs cycle where they are used to produce ATP molecules.
Want to see the full answer?
Check out a sample textbook solutionChapter 25 Solutions
Study Guide with Selected Solutions for Stoker's General, Organic, and Biological Chemistry, 7th
- One of the steps that occur during the synthesis of ketone bodies is shown below. OH D-beta-hydroxybutyrate Dehydrógenase .coo coo0 H3C cooo Нас acetoacetate D-beta-hydroxybutyrate Does this process require FAD or NAD*, FADH2 or NADH as the reactant coenzyme? Explain your answer in a few words.arrow_forwardHow many molecules of NADH and FADH2 are obtained from the β-oxidation of one molecule of a 16-carbon saturated fatty acyl-CoA?arrow_forwardWhat is the most common starting material for gluconeogenesis?arrow_forward
- Based on the names of the enzymes participating in glycolysis, what would be the name of the enzyme catalyzing the activation of glycerol? A. Glycerol kinase B. Glycerol dehydrogenase C. Glycerol hydratase D. Glycerasearrow_forwardWhich statement is TRUE regarding ketone bodies? O Ketone bodies are only formed during times of starvation. Excess acetoacetate produced during ketone body production is mostly exhaled. O Ketone bodies can easily travel from one tissue to another in the body due to the preser Coenzyme A. O Ketone bodies tend to be formed when oxaloacetate concentrations are high. O Ketone bodies can be used as a source of acetyl-CoA in target tissues when blood glucosarrow_forward18. Amino acids that are degraded into are termed ketogenic. O a. a-ketoglutarate b. oxaloacetate c. fumarate d. acetyl CoAarrow_forward
- General, Organic, and Biological ChemistryChemistryISBN:9781285853918Author:H. Stephen StokerPublisher:Cengage LearningOrganic And Biological ChemistryChemistryISBN:9781305081079Author:STOKER, H. Stephen (howard Stephen)Publisher:Cengage Learning,Chemistry for Today: General, Organic, and Bioche...ChemistryISBN:9781305960060Author:Spencer L. Seager, Michael R. Slabaugh, Maren S. HansenPublisher:Cengage Learning
- Introduction to General, Organic and BiochemistryChemistryISBN:9781285869759Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar TorresPublisher:Cengage Learning