Biology: The Dynamic Science (MindTap Course List)
4th Edition
ISBN: 9781305389892
Author: Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher: Cengage Learning
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Textbook Question
Chapter 16, Problem 15TYK
Design an experiment using rats as the model organism to test the hypothesis that human chorionic gonadotropin (hCG), a hormone produced during pregnancy, leads to a significant protection against breast cancer.
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Chapter 16 Solutions
Biology: The Dynamic Science (MindTap Course List)
Ch. 16.1 - Suppose the lacl gene is mutated so that the Lac...Ch. 16.1 - Answer the equivalent question for the trp operon:...Ch. 16.2 - What is the role of histones in gene expression?...Ch. 16.2 - Prob. 2SBCh. 16.3 - Prob. 1SBCh. 16.3 - Prob. 2SBCh. 16.4 - Prob. 1SBCh. 16.4 - Prob. 2SBCh. 16.5 - Prob. 1SBCh. 16.5 - Prob. 2SB
Ch. 16.5 - Prob. 3SBCh. 16.5 - Prob. 4SBCh. 16 - Prob. 1TYKCh. 16 - For the E. coli lac operon, when lactose is...Ch. 16 - Prob. 3TYKCh. 16 - Prob. 4TYKCh. 16 - Prob. 5TYKCh. 16 - Prob. 6TYKCh. 16 - Prob. 7TYKCh. 16 - Prob. 8TYKCh. 16 - Prob. 9TYKCh. 16 - Prob. 10TYKCh. 16 - Discuss Concepts In a mutant strain of E. coli,...Ch. 16 - Prob. 12TYKCh. 16 - Prob. 13TYKCh. 16 - Prob. 14TYKCh. 16 - Design an experiment using rats as the model...Ch. 16 - Prob. 1ITDCh. 16 - Prob. 2ITDCh. 16 - Prob. 3ITDCh. 16 - Prob. 4ITD
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- Read the scenario presented in the picture. The conditions employed in laboratory settings could mimic the outcomes of prolonged usage of tamoxifen and hormone deprivation therapy. We don't know much about the phenotypic profile of these newly emerged cancer cells. How might you explain the lack of response of TamC3 to tamoxifen treatment and TamR3 to estrogen deprivation?arrow_forwardSuppose that you are hired by a biotechnology firm to produce a strain of giant fruit flies by using recombinant DNA technology so that genetics students will not be forced to strain their eyes when looking at tiny flies. You go to the library and learn that growth in fruit flies is normally inhibited by a hormone called shorty substance P (SSP). You decide that you can produce giant fruit flies if you can somehow turn off the production of SSP. Shorty substance P is synthesized from a compound called XSP in a single-step reaction catalyzed by the enzyme runtase: A researcher has already isolated cDNA for runtase and has sequenced it, but the location of the runtase gene in the Drosophila genome is unknown. In attempting to devise a strategy for turning off the production of SSP using standard recombinant DNA techniques, you discover that deleting, inactivating, or otherwise mutating this DNA sequence in Drosophila turns out to be extremely difficult. Therefore, you must restrict your…arrow_forwardThe C-myc gene is a proto-oncogene which is highly expressed in breast tissue and appears to cause proliferation of breast tissue and its elevated expression is associated with breast cancer. Based just on the ChIP data from the previous questions (also shown below), which of the three drugs (estrogen, tamoxifen and raloxifene) would you recommend for treating breast cancer? Justify your response and explain the potential side effects of each drug.arrow_forward
- Herceptin is an antibody that is used to treat certain forms of breast cancer by binding to a class of estrogen receptors. What is the basis for its effectiveness in treating certain forms of breast cancer?arrow_forwardWhat are some of the ethical issues that arise from using embryonic stem cells?(b) To avoid these issues, scientists use IPSCs. What are the pros and cons to using iPSCs inrelation to embryonic stem cells?arrow_forwardEstrogen works by binding to the ER. It includes two types ER alpha and ER beta and the two receptors are highly homologous. How might this be relevant in cancer?arrow_forward
- Signal transduction pathways are important mechanisms for cell-to-cell communication in multicellular organisms. How do the target cells typically respond when they receive signals from neighboring cells during very early stages of embryo development? A. The target cells move to one of the poles to establish the anterior-posterior body axis. B. The target cells undergo changes in gene expression, sending them down a specific developmental path. C. The target cells stop dividing so the neighboring cells have time to get to the same stage of development. D. The target cells activate a collection of miRNAs to accelerate transcription and cell division.arrow_forwardThe Human papillomavirus (HPV) has been linked to an increased risk of cervical cancer. The HPV E6 and E7 proteins govern the cell via altering cellular proteins. The E6 protein interacts with the tumor suppressor protein p53 and directs its ubiquitin-mediated destruction. Can you elaborate about the P63 gene: its function and if it can be altered/mutated by HPV? If it does, what is the relationship between P53 and P63? Thank you!arrow_forwardIn many breast cancers, ER (alpha) activation by estrogens is generally considered responsible for enhanced proliferation, whereas that is counteracted by the presence of ER (beta),which exerts an antiproliferative effect. Please devise a strategy targeting both receptors for the treatment of this disease.arrow_forward
- Identify two genetic mechanisms whereby proto-oncogenes can become overexpressed. Select the two mechanisms. Identify two genetic mechanisms whereby proto-oncogenes can become overexpressed.Select the two mechanisms. 1) alterations in chromatin structure 2) a gain-of-function alteration 3)modification of proto-oncogenes products 4)mutations that result in an abnormal protein product 5)mutations within gene-regulatory regionsarrow_forwardA Patients with an inherited cancer have a mutation in a zinc-finger motif of P21 (a cell-cycle regulatory gene). Which of the following is the most likely result of this A) Decreased binding of a transcription factor to a DNA sequence B) Enhanced binding of hormones to receptors C) Enhanced transport of a hormone receptor complex into the nucleus D) Stimulation of mRNA synthesis E) "Unzipping" of leucine-rich helicesarrow_forwardMany currently marketed drugs exert their pharmacological effects by binding to ligand-activated transcription factors and modulating gene expression. One example, are various drugs that target the estrogen receptor to treat breast cancer, osteoporosis and post-menopausal symptoms. Below is a ChIP experiment examining the effects of no drug treatment (C), the natural hormone estrogen (E) and the drugs tamoxifen (T) and raloxifene (R) on recruitment of coactivators (SRC-1 and CBP), Histone Deacetylase Complexes (HDACs) and acetylation of histones associated with the C-myc gene. Which of the following statements are correct based on this data (select all that apply)?arrow_forward
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