You are studying the mobility of a transmembrane protein that contains extracellular domains, one transmembrane domain, and a large cytosolic domain. Under normal conditions, this protein is confined to a particular region of the membrane due to the cortical actin cytoskeletal network. Which of the following changes is most likely to increase mobility of this protein beyond the normal restricted region of the membrane? A. Increased temperature B. Protease cleavage of the extracellular domain of the protein C. Binding to a free-floating extracellular ligand, such as a hormone D. Protease cleavage of the cytosolic domain of the protein E. Aggregation of the protein with other transmembrane proteins

Human Physiology: From Cells to Systems (MindTap Course List)
9th Edition
ISBN:9781285866932
Author:Lauralee Sherwood
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Chapter2: Cell Physiology
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You are studying the mobility of a transmembrane protein that contains extracellular domains, one transmembrane domain, and a large cytosolic domain. Under normal conditions, this protein is confined to a particular region of the membrane due to the cortical actin cytoskeletal network. Which of the following changes is most likely to increase mobility of this protein beyond the normal restricted region of the membrane?
A. Increased temperature
B. Protease cleavage of the extracellular domain of the protein
C. Binding to a free-floating extracellular ligand, such as a hormone
D. Protease cleavage of the cytosolic domain of the protein
E. Aggregation of the protein with other transmembrane proteins
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