Chapter 16, Problem 12TYK

Summary Introduction

To review:

Fruit flies possess a mutation in the tumor suppressor gene HIPPO, which is homozygous and leads to the development of tumors in every organ. The expression of the human gene, MST2 in flies with the homozygous mutation in the HIPPO gene leads to a great reduction in the development of tumors. Further, the evolution of tumor suppressor genes in animals is also to be assessed.

Introduction:

Tumor suppressor genes are present in all cells of animals and the product of these genes are called tumor suppressor proteins, which participate in the regulation of cell growth by inhibiting excessive growth of the cell.