Biology: The Dynamic Science (MindTap Course List)
4th Edition
ISBN: 9781305389892
Author: Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher: Cengage Learning
expand_more
expand_more
format_list_bulleted
Concept explainers
Question
Chapter 16, Problem 13TYK
Summary Introduction
To review:
Developing a hypothesis to explain that the muscle samples from women, who carry a mutation for muscular dystrophy disease, reveal some regions of degenerating muscle tissue adjacent to the other regions that are normal.
Introduction:
Duchenne muscular dystrophy is an example of the X-linked recessive disorder. Cells have DMD (Duchenne muscular dystrophy) gene, which produces a protein-dystrophin in muscle cells. Dystrophin provides the strength to the muscle tissues. Mutation in the DMD gene causes the muscle tissues to break down and thus, weak muscles are formed.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solutionStudents have asked these similar questions
In humans, the AMY1 gene produces the enzyme amylase in cells of the salivary glands. Amylase breaks down starch (a polysaccharide) into the sugar maltose (a disaccharide). People from cultures with diets high in starch produce more amylase than people from cultures with diets low in starch because of a mutation in the AMY1 gene. Explain in two to three sentences why the frequency of this AMY1 mutation would have increased in frequency in populations with a high starch diet.
Suppose that a mutation resulted in a tapeworm that did not have hooks. Assuming this tapeworm was a human parasite, what is the most likely explanation of the effect might this have?
The tapeworm would spread throughout the human body.
The tapeworm would complete its entire life cycle inside the human host.
The tapeworm would not remain in the digestive tract very long.
The tapeworm would not be able to enter the human body.
The tapeworm would reproduce more to compensate for a lack of hooks.
A controversial issue, closely related to cloning, that has caused a lot of debate is the use of embryonic stem cells. One possible application of these cells is that they may be able to supply replacement tissues to treat diseases such as Parkinson's disease, diabetes, paralysis due to spinal cord injuries, and other degenerative diseases. The word "embryonic", has caused fierce opposition to this type of research because embryos are destroyed when the stem cells are removed. Questions that have surfaced in this debate include: When a cell nucleus is transferred to another cell, have we created life? Does a stem cell have the same status as a human? What should be done with the embryos that are leftover at in vitro fertilization (IVF), clinics? Advocates argue that the medical benefits of stem cell research would be enormous. Opponents argue that life begins at conception and thus this type of research is abortion.
Based on what you have read, explain why you are for or against stem…
Chapter 16 Solutions
Biology: The Dynamic Science (MindTap Course List)
Ch. 16.1 - Suppose the lacl gene is mutated so that the Lac...Ch. 16.1 - Answer the equivalent question for the trp operon:...Ch. 16.2 - What is the role of histones in gene expression?...Ch. 16.2 - Prob. 2SBCh. 16.3 - Prob. 1SBCh. 16.3 - Prob. 2SBCh. 16.4 - Prob. 1SBCh. 16.4 - Prob. 2SBCh. 16.5 - Prob. 1SBCh. 16.5 - Prob. 2SB
Ch. 16.5 - Prob. 3SBCh. 16.5 - Prob. 4SBCh. 16 - Prob. 1TYKCh. 16 - For the E. coli lac operon, when lactose is...Ch. 16 - Prob. 3TYKCh. 16 - Prob. 4TYKCh. 16 - Prob. 5TYKCh. 16 - Prob. 6TYKCh. 16 - Prob. 7TYKCh. 16 - Prob. 8TYKCh. 16 - Prob. 9TYKCh. 16 - Prob. 10TYKCh. 16 - Discuss Concepts In a mutant strain of E. coli,...Ch. 16 - Prob. 12TYKCh. 16 - Prob. 13TYKCh. 16 - Prob. 14TYKCh. 16 - Design an experiment using rats as the model...Ch. 16 - Prob. 1ITDCh. 16 - Prob. 2ITDCh. 16 - Prob. 3ITDCh. 16 - Prob. 4ITD
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- The attached table below shows the reference and a diseased patient's DMD genes in the hip flexor which, if mutated, can cause muscular dystophy. Analyze the table, make the coding strand, and explain how and which mutation in the patien's genes caused muscular dystrophyarrow_forwardThe accompanying photo shows a sequencing gel from the original study that first sequenced the cystic fibrosis gene (J. R. Riordan et al. 1989. Science 245:1066–1073). From the photo, determine the sequence of the normal copy of the gene and the sequence of the mutated copy of the gene. Identify the location of the mutation that causes cystic fibrosis. (Hint: The CF mutation is a 3-bp deletion.)arrow_forwardThe phenotype of a heterozygous mouse (Aa) is agouti. The agouti banding pattern is due to altered expression of the agouti gene. Which of the following statement is false? a) Expression of the agouti gene inhibits the production of eumelanin. b) Evidence suggests that the agouti gene is only expressed in tissues associated with fur production. c) Epigenetic markers silence the agouti gene resulting in dark pigmentation at the tip and root of the hair. d) All of the abovearrow_forward
- If a mutation in a homeotic gene produced the following phenotypes, would you expect it to be a loss-of-function or a gain-offunction mutation? Explain your answer. A. An abdominal segment has antennae attached to it. B. The most anterior abdominal segment resembles the most posterior thoracic segment. C. The most anterior thoracic segment resembles the most posterior abdominal segment.arrow_forwardBefore this experiment, Dr Merrick didn’t know whether the OBP that he cloned was a type of myoglobin or hemoglobin from mammoth. From his data, he is now quite sure that OBP cannot be myoglobin from mammoth. How does he know? Explain your reasoning.arrow_forwardConsider the genes that specify the structure of hemoglobin. Arrange the following events in the most likely sequence in which they would take place.a. Anemia is observed.b. The shape of the oxygen-binding site is altered.c. An incorrect codon is transcribed into hemoglobinmRNA.d. The ovum (female gamete) receives a high radiationdose.e. An incorrect codon is generated in the DNA of ahemoglobin gene.f. A mother (an X-ray technician) accidentally stepsin front of an operating X-ray generator.g. A child dies.h. The oxygen-transport capacity of the body is severelyimpaired.i. The tRNA anticodon that lines up is one of a typethat brings an unsuitable amino acid.j. Nucleotide-pair substitution occurs in the DNA of agene for hemoglobinarrow_forward
- For the first experiment ever on Drosophila mutations. Answer the following questions. a. What is the title of the first published paper explained the experiment and what is the name of the Author? b. What is the first mutation discovered in Drosophila? c. Explain the changes in the Drosophila yellow mutant (Y)compared to wild type.arrow_forwardParents who both have "sickle-cell trait", i.e, are heterozygous for HbS have a child who is tested at birth, and is found to be homozygous for HbS (both alleles affected). What is the molecular reason why the child presents with no symptoms until 6 months of age? a.) the mutation affects the beta chain, which is not dominant at birth b.) the mutation affects the alpha chain, which is not dominant at birth c.) babies cannot be exposed to low oxygen that triggers symptoms d.) babies cannot be exposed to high oxygen that triggers symptomsarrow_forwardWhich among the following statements is not true about mutations? * a.) It may either occur at the chromosomes or at the sequence of nucleic acids. b.) It is caused either by mutagens or through hereditary genes. c.) All mutations cause diseases and disorders in the developing organism. d.) All mutations causes a change in the structure or sequence of the genetic material.arrow_forward
- It has been suggested that it would make the study of human diseases easier if cloned transgenic animals were produced that carried faulty versions of human genes (e.g., the gene that causes cystic fibrosis). a. Why would such animals be useful in medical research? : b. What ethical questions are raised by the creation of such transgenic animals?arrow_forwardWhich of the examples of genetic testing below are prognostic tests? Which are diagnostic? (a) Individual sequencing (personal genomics) identifies a mutation associated with Alzheimer’s disease. (b) ASO testing determines that an individual is a carrier for the mutant b@globin allele (bS) found in sickle-cell anemia. (c) DNA sequencing of a breast tumor reveals mutations in the BRCA1 gene. (d) Genetic testing in a healthy teenager identifies an SNP correlated with autism. (e) An adult diagnosed with Asperger syndrome (AS) has a genetic test that reveals a SNP in the GABRB3 gene that is significantly more common in people with AS than the general population.arrow_forwardThe diagram shown represents the coding strand of the myosin gene. Mutations in myosin can lead to muscle defects during development. Using what you know about how mutations can affect transcriptional and post-transcriptional regulation, match the results shown on the Northern (mature mRNA) to the mutations shown. The N lane shows the size and amount expected for non-mutated myosin mRNA. All samples were loaded at the top (-) side of the gel. Part 1. Which lane or lanes on the gel could be the result of mutation A? 00000 I lane 1 lane 2 lane 3 lane 4 lane 5 TATAA Mutation A. Deletion of indicated 2 nucleotides AUG TSS Mutation B. Deletion of 150 nucleotides N 1 2 3 4 5 UAA Mutation C. 3 nucleotides changedarrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- Biology: The Dynamic Science (MindTap Course List)BiologyISBN:9781305389892Author:Peter J. Russell, Paul E. Hertz, Beverly McMillanPublisher:Cengage LearningHuman Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning
Biology: The Dynamic Science (MindTap Course List)
Biology
ISBN:9781305389892
Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher:Cengage Learning
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
What is Genomics - Full Length; Author: Genome BC;https://www.youtube.com/watch?v=mmgIClg0Y1k;License: Standard youtube license