Compare the energy cost, in ATP equivalents, of synthesizing stearate from mitochondrial acetyl-CoA to the energy recovered by degrading stearate to acetyl-CoA. assume NADH (or NADPH) and FADH2 yield 2.5 and 1.5 ATP equivalents, respectively. Remember that FAS stops at palmitate; the pathway for further elongation is shown in the book (Fig. 20-28). Don’t forget steps needed to generate malonyl-CoA or transport of acetyl-CoA out of the mitochondria. Please show me detailed solution.
8. Compare the energy cost, in ATP equivalents, of synthesizing
stearate from mitochondrial acetyl-CoA to the energy recovered by
degrading stearate to acetyl-CoA.
assume NADH (or NADPH) and FADH2 yield 2.5 and 1.5
ATP equivalents, respectively. Remember that FAS stops at palmitate; the pathway for
further elongation is shown in the book (Fig. 20-28). Don’t forget steps needed to
generate malonyl-CoA or transport of acetyl-CoA out of the mitochondria.
Please show me detailed solution.
Stearate is a saturated fatty acid with 18-C atom chain. Its biosynthesis takes place from carbohydrate. Carbohydrate is first converted into Acetyl-CoA and then it forms Acetyl-ACP and Combine with Malonyl-CoA to form Butyryl-ACP. Here Fatty acyl synthase 1 (FAS1) enzyme catalyze complete process. The process consumes 2NADPH molecule. This butyryl-ACP then enter a cyclic event five more times where it combines again and again with Malonyl-CoA to elongate chain to 16 C-atom Palmitate. Normally cell stop chain elongation at this stage and hydrolyze ACP to form Palmitoyl-CoA and is released in cytoplasm. Here its further elongation takes place in a reaction given below to from 18C Stearic Acid
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