2. The amino acid glutamate is synthesized from a-ketoglutarate, a catalytic intermediate in the citric acid cycle. In order for glutamate to be synthesized without depleting citric acid cycle intermediates, more carbon must be added to the cycle to make excess a-ketoglutarate. a. Describe the net synthesis of a-ketoglutarate from pyruvate in which no citric acid cycle intermediates are depleted. You must show how pyruvate can be used to introduce more carbons into the citric acid cycle than are lost (don't overlook CO₂).

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A:

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Mitochondrial Mutations

A mitochondrion is a cellular organelle that serves as the site for cellular respiration and energy production (ATP or Adenosine Triphosphate). It is a double-membrane-bound organelle and is only present in eukaryotic cells.