Compounds A4 and A5 are inhibitors of a hydrolytic enzyme that hydrolyses A1 into products A2 and A3. (1) Provide a suitable mechanism for the observed reversible hydrolase inhibition by A4 (2) Provide a suitable mechanism for the observed irreversible hydrolase inhibition by A5 assuming that a covalent bond is formed between A5 and the active site reside. Hint: assume that the active site of the hydrolase contains an aspartic acid residue and a water molecule which catalyzes the hydrolysis of the glycoside A1.
Nucleotides
It is an organic molecule made up of three basic components- a nitrogenous base, phosphate,and pentose sugar. The nucleotides are important for metabolic reactions andthe formation of DNA (deoxyribonucleic acid) and RNA (ribonucleic acid).
Nucleic Acids
Nucleic acids are essential biomolecules present in prokaryotic and eukaryotic cells and viruses. They carry the genetic information for the synthesis of proteins and cellular replication. The nucleic acids are of two types: deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). The structure of all proteins and ultimately every biomolecule and cellular component is a product of information encoded in the sequence of nucleic acids. Parts of a DNA molecule containing the information needed to synthesize a protein or an RNA are genes. Nucleic acids can store and transmit genetic information from one generation to the next, fundamental to any life form.
Compounds A4 and A5 are inhibitors of a hydrolytic enzyme that hydrolyses A1 into products A2 and A3.
(1) Provide a suitable mechanism for the observed reversible hydrolase inhibition by A4
(2) Provide a suitable mechanism for the observed irreversible hydrolase inhibition by A5 assuming that a covalent bond is formed between A5 and the active site reside.
Hint: assume that the active site of the hydrolase contains an aspartic acid residue and a water molecule which catalyzes the hydrolysis of the glycoside A1.
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