Draw two reaction coordinate diagrams (DG vs reaction coordinate) that compare the uncatalyzed process of lipid flipping (lipid out à lipid in ) from outer to inner leaflet to the flippase-catalyzed process.

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
icon
Related questions
Question
Draw two reaction coordinate diagrams (DG vs reaction coordinate) that compare the uncatalyzed process of lipid flipping (lipid out à lipid in ) from outer to inner leaflet to the flippase-catalyzed process.
ii) Draw two reaction coordinate diagrams (AG vs reaction coordinate) that compare the uncatalyzed process
of lipid flipping (lipidout → lipidin) from outer to inner leaflet to the flippase-catalyzed process. (Note that an
ATPases like flippases enhance both the rates of a reaction (like a typical enzyme) and thermodynamic profile
of a reaction (because they can couple ATP hydrolysis to a particular reaction, adding ATP/ADP+P; in the
reactants/products)
uncatalyzed barrier on the order of 50 kcal/mol
lipid
catalyzed barrier?
+
NH3
ATP
out
ADP + P₁
Flippase
lipid
out
very slow
(t1/2 in days)
fast
(t₁/2 in minutes)
lipidin
lipid in
Transcribed Image Text:ii) Draw two reaction coordinate diagrams (AG vs reaction coordinate) that compare the uncatalyzed process of lipid flipping (lipidout → lipidin) from outer to inner leaflet to the flippase-catalyzed process. (Note that an ATPases like flippases enhance both the rates of a reaction (like a typical enzyme) and thermodynamic profile of a reaction (because they can couple ATP hydrolysis to a particular reaction, adding ATP/ADP+P; in the reactants/products) uncatalyzed barrier on the order of 50 kcal/mol lipid catalyzed barrier? + NH3 ATP out ADP + P₁ Flippase lipid out very slow (t1/2 in days) fast (t₁/2 in minutes) lipidin lipid in
Expert Solution
trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 3 steps with 2 images

Blurred answer
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman
Lehninger Principles of Biochemistry
Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul…
Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305961135
Author:
Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:
Cengage Learning
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305577206
Author:
Reginald H. Garrett, Charles M. Grisham
Publisher:
Cengage Learning
Fundamentals of General, Organic, and Biological …
Fundamentals of General, Organic, and Biological …
Biochemistry
ISBN:
9780134015187
Author:
John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:
PEARSON