The enzyme aspartate transcarbamoylase catalyzes an early step in pyrimidine biosynthesis. The two states of the multi-subunit enzyme are shown below. Note that the binding of the regulatory molecule CTP (cytosine triphosphate) causes the enzyme complex to be inactive. Is this situation an example of positive or negative regulation? Explain why the use of CTP as the regulatory molecule is logical given the overall function of this particular enzyme. INACTIVE ENZYME: T STATE catalytic subunits regulatory subunits OFF 6 CTP 6 CTP ON 5 nm ACTIVE ENZYME:R STATE

Biochemistry
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ISBN:9781319114671
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The enzyme aspartate transcarbamoylase catalyzes an early step in *pyrimidine biosynthesis*. The two states of the multi-subunit enzyme are shown below. Note that the binding of the regulatory molecule CTP (cytosine triphosphate) causes the enzyme complex to be inactive. Is this situation an example of positive or negative regulation? Explain why the use of CTP as the regulatory molecule is logical given the overall function of this particular enzyme.

Diagram Explanation:

**Inactive Enzyme: T State**
- The diagram shows the enzyme in its inactive form with the label "OFF."
- The regulatory and catalytic subunits are depicted.
- 6 CTP molecules are shown binding to the enzyme, indicating regulatory interaction leading to inactivation.

**Active Enzyme: R State**
- The diagram shows the enzyme in its active form with the label "ON."
- The structure appears more open, indicating activation.
- The subunits have a spacing of 5 nm.
- The configuration suggests that the enzyme is functional without CTP bound.
Transcribed Image Text:The enzyme aspartate transcarbamoylase catalyzes an early step in *pyrimidine biosynthesis*. The two states of the multi-subunit enzyme are shown below. Note that the binding of the regulatory molecule CTP (cytosine triphosphate) causes the enzyme complex to be inactive. Is this situation an example of positive or negative regulation? Explain why the use of CTP as the regulatory molecule is logical given the overall function of this particular enzyme. Diagram Explanation: **Inactive Enzyme: T State** - The diagram shows the enzyme in its inactive form with the label "OFF." - The regulatory and catalytic subunits are depicted. - 6 CTP molecules are shown binding to the enzyme, indicating regulatory interaction leading to inactivation. **Active Enzyme: R State** - The diagram shows the enzyme in its active form with the label "ON." - The structure appears more open, indicating activation. - The subunits have a spacing of 5 nm. - The configuration suggests that the enzyme is functional without CTP bound.
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