OH OH NAD++ P NADH + H+ HO HO OH NAD++ P NADH + H+ OH OH OH
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Question
During glycolysis, the enzyme glyceraldehyde phosphate dehydrogenase (GAPDH) catalyzes the oxidation and phosphorylation of glyceraldehyde 3-phosphate, forming 1,3-bisphosphoglycerate. This reaction, shown below, has a ΔG that is close to zero under cellular conditions.
During gluconeogenesis, GAPDH catalyzes the reverse reaction, in which 1,3-bisphosphoglycerate is reduced and dephosphorylated. Given this information, which of the following conditions are most likely to directly alter the relative rates of the forward and reverse reactions? (select two answers)
- changes in the relative concentrations of glyceraldehyde 3-phosphate and 1,3-bisphosphoglycerate
- changes in the relative concentrations of NAD+ and NADH
- decreased cellular concentration of pyruvate
- increased cellular concentration of glucose
- regulation of GAPDH activity
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