The overall reactions for gluconeogenesis and glycolysis are given below. What is the energy cost (inATP equivalents) of transforming one molecule of glucose to pyruvate (via glycolysis) and back toglucose (via gluconeogenesis)?Gluconeogenesis:2 pyruvate + 4 ATP + 2 GTP + 2NADH + 4H₂OGlycolysis:Glucose + 2ADP + 2P₁ + 2NAD+ - 2 pyruvate + 2ATP + 2NADH + 2H+ + 2H₂000Select one:O a. 2 ATPO b. 4 ATPO c. 6 ATPO d. 8 ATPPrev Pageglucose + 4ADP + 2GDP + 2P₁ +2NAD+ + 2H+MI21 2200:508D DAD1=1SE30: DONDOK23 24 25 26 27 28 29 30Report question issue BNext PageG

Glycolysis is a catabolic pathway in which Glucose is broken down into two molecules of…

Answered: The overall reactions for…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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The first reaction in glycolysis is the phosphorylation of glucose: Pi + glucose → glucose-6-phosphate + H2O This is a thermodynamically unfavorable process, with ∆G°′ = +13.8 kJ/mol. (a) In a liver cell at 37 °C the concentrations of both phosphate and glucose are normally maintained at about 5 mM each. What would be the equilibrium concentration of glucose-6-phosphate, according to the above data? (b) This very low concentration of the desired product would be unfavorable for glycolysis. In fact, the reaction is coupled to ATP hydrolysis to give the overall reaction ATP + glucose → glucose-6-phosphate + ADP + H+ What is ∆G°′ for the coupled reaction? (c) If, in addition to the constraints on glucose concentration listed previously, we have in the liver cell ATP concentration = 3 mM and ADP concentration = 1 mM, what is the theoretical concentration of glucose6-phosphate at equilibrium at pH = 7.4 and 37 °C? The answer…
The first reaction in glycolysis is the phosphorylation of glucose to form glucose 6-phosphate: P₁+ glucose glucose 6-phosphate + H₂O This is a thermodynamically unfavorable reaction, with AG° = +13.8 kJ/mol. a) In a liver cell at 37°C the concentrations of both phosphate and glucose are normally maintained at about 5 mM each. What is the equilibrium concentration of glucose 6- phosphate, according to the above reaction? b) This very low concentration of glucose 6-phosphate is unfavorable for glycolysis. In fact, the reaction is coupled to the hydrolysis of ATP: ATP + H₂O2 ADP + P₁ +H* AG°¹ = -32.2 kJ/mol Write the expression for the overall reaction and calculate AG°¹. c) In addition to the glucose and phosphate concentrations listed in part (a) above, assume that the liver cell concentrations of ATP and ADP are 3 mM and 1 mM, respectively. Calculate the theoretical equilibrium concentration of glucose 6-phosphate at pH = 7.4 and 37 °C. C ZOOM +
Why does activation of the phosphorylated b form of glycogen synthase by high concentrations of glucose 6-phosphate make good biochemical sense? It ensures that glucose is saved when it is abundant and not being used to fuel energy metabolism. It ensures that excess fuel is stored in the most reduced and energy-rich form. It prevents glycogen from being synthesized at the same time as it is being broken down. It prevents the mobilization of glycogen when glucose is already abundant.
A figure of the energy payoff phase of glycolysis is shown below. Look at the reaction labelled with a 6 (on the far left), which involves the conversion of glyceraldehyde-3-phosphate to 1,3-bisphosphoglycerate. reduced? HC O CHOH CH₂O-P Glycer- aldehyde 3-phosphate (G3P) 2 NADH 2 NAD+ + 2 H+ Triose phosphate 2 P₁ dehydrogenase Copyright © 2018 Pearson Canada Inc. P CHOH CH₂0-P 1,3-Bisphospho- glycerate 1,3- bisphosphoglycerate NADH NAD+ 2 ADP GLYCOLYSIS: Energy Payoff Phase Glyceraldehyde-3-phosphate 2 ATP Phospho- glycerokinase 2 Which of the compounds is C=O CHOH H–CO- P Phospho- CH₂0-P glyceromutase CH₂OH 8 3-Phospho- glycerate C=O 2-Phospho- glycerate 2. ATP 2 ADP BYD Pyruvate kinase 10 2 H₂O Enolase 2 C=O CO-P CH2 Phosphoenol- pyruvate (PEP) CH3 Pyruvate
Which of the following accurately characterize glycolysis under standard biochemical conditions? (Pick two.) Glycolysis reduces glucose and produces oxidized electron carriers. Glycolysis oxidizes glucose and produces reduced electron carriers. The exergonic conversion of glucose into pyruvate is coupled to the endergonic synthesis of two ATP in a pathway that is exergonic, net. The endergonic conversion of glucose into pyruvate is coupled to the endergonic synthesis of two ATP in a pathway that is exergonic, net.
Please help fill out the metabolic Pathway table of Gluconeogenesis and Tricarboxylic by listing its enzymes and functions
Mention two biological advantages to an organism that stores its carbohydrate reserves as starch or glycogen rather than as an equivalent amount of free glucose. What role does the protein, glycogenin play in glycogen synthesis? Name the reactants and products of the first two steps of the gluconeogenesis pathway if pyruvate is used as the starting material (structures not needed). Explain why people with a deficiency of the enzyme glucose 6-phosphate dehydrogenase (G6PDH) suffer from hemolytic anemia What is meant by reciprocal regulation? Name one compound that reciprocally regulates glycolysis and gluconeogenesis pathways. Which enzymes are regulated by this compound? What reactions are catalyzed by these enzymes?
Indicate what will happen (increase, decrease or no effect) to the activity of the enzyme or rate of the metabolic pathway given the following conditions.
Please select the correct op
In different organisms sucrose can be cleaved either by hydrolysis or by phosphorolysis. Calculate the ATP yield per mole of sucrose metabolized by anaerobic glycolysis starting with (a) hydrolytic cleavage and (b) phosphorolytic cleavage.
What is the overall net reaction of glycolysis? C6H12O6 + 2 NADH + 2 P₁ + 2 ATP --> 2 C3H3O3 + 2 NAD+ + 2 H+ + 2 H₂O + 2 ADP C6H12O6 + 2 NAD+ + 4 P₁ + 4 ADP --> 2 C3H3O3 + 2 NADH + 2 H+ + 2 H₂O + 4 ATP Glucose + 2 NAD+ + 2 P₁ + 2 ADP --> 2 C3H3O3 + 2 NADH + 2 H+ + 2 H₂O + 2 ATP Glucose + 2 FAD + 2 P; + 2 ADP --> 2 Pyruvate + 2 FADH₂ + 2 H+ + 2 H₂O + 2 ATP C6H12O6 + 2 NAD+ + 2 P₁ + 2 ADP --> Pyruvate + 2 NADH + 2 H+ + 2 H₂O + 2 ATP
Pyruvate carboxylase catalyzes the first step of gluconeogenesis. ATP + HCO3─ + pyruvate → oxaloacetate + ADP + Pi ∆G0’ = ─2.1 kJ mol-1 a) Calculate ΔG for this reaction under the following physiological conditions: 370C, pH 7 [pyruvate] = [HCO3─] = 4.0 mM [oxaloacetate]= 2.0 mM [ATP] = 3.5 mM [Pi] = 5.0 mM [ADP] = 1.8 mM

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