Which of the following accurately characterize glycolysis under standard biochemicalconditions? (Pick two.)Glycolysis reduces glucose and produces oxidized electron carriers.Glycolysis oxidizes glucose and produces reduced electron carriers.The exergonic conversion of glucose into pyruvate is coupled to the endergonic synthesis of two ATPin a pathway that is exergonic, net.The endergonic conversion of glucose into pyruvate is coupled to the endergonic synthesis of twoATP in a pathway that is exergonic, net.

The metabolic process known as glycolysis converts the six-carbon glucose molecule into two…

Answered: Which of the following accurately…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Using diagrams show the pathway that is used to convert succinate to phosphoenol-pyruvate, which can be used to make glucose through gluconeogenesis. Be sure to show the structure of all of the intermediates along the pathway and show the name of each enzyme over the arrow. Also be sure to indicate other co-substrates or cofactors required (ie. ATP, NAD+, FAD, etc…)
The following two reactions are coupled in the last step of glycolysis (catalyzed by the enzyme pyruvate kinase). РЕР + Н.О € Руr + Pi ADP + Pi → ATP + H2O AG° = -14.8 kcal/mol AG° = +7.3 kcal/mol D) The steady-state concentrations of ATP, ADP, and pyruvate in human erythrocytes are 2.24 mM, 0.25 mM, and 0.051 mM, respectively. What would be the concentration of PEP in these cells if the coupled reaction was at equilibrium?
In glycolysis, the KM value of hexoquinase is 0.04 mM. At physiological conditions, the cellular concentration of glucose is between 4 mM to 15 mM. According with this information, which of the following statements is true (Choose all that are correct) The enzyme has a low affinity for its substrate The enzme is working at its maximum velocity The phosphorilation of glucose is very slow The small value of KM assures that glycolysis will continue even when the concentration of glucose drops below 4 mM. The hexoquinase is saturated with glucose
Otto Warburg made an interesting observation in the 1930s about cancer cells using the fermentation pathway to catabolize pyruvate even when the oxygen supply seemed sufficient for oxidative phosphorylation. One modern explanation for this “Warburg Effect” is that it protects the cancer cells from damage from free radicals. Provide a biochemical rationale for this explanation.
Describe redox reactions involved in the three steps of aerobic cellular respiration under the following topics: 1. Description of the two coenzymes NAD and FAD and link them to each enzyme in glycolysis; pyruvate oxidation and citric acid cycle using the backpack analogy that I described in class. (20%) 2. Describe energy harvesting of the electrons and hydrogens carried by the coenzymes in the electron transport chain and chemiosmosis using the battery analogy I described in class. (20%) 3. Describe the steps of DNA replication in bacteria as shown in our slides emphasizing the need for the Okazaki fragments (20%) 4. Describe RNA transcription emphasizing the two strands of DNA and the orientation of mRNA (20%) 5. Describe mRNA translation emphasizing the role of ribosomes and tRNA for two amino acids (20%)
Break down the glycolysis pathway in terms of the following reaction steps (you may write or take photos of chemical reactions; be sure to include the enzyme involved): - ATP-requiring steps - ATP-producing steps - NAD-involving steps, and - Irreversible steps
The AG of the reaction C6H12O6 + 60₂ --> 6CO₂ + 6H₂O is -686 kcal/mol glucose oxidized. The AG of the reaction ADP + P₁ --> ATP + H₂O is + 7.3 kcal/mol ATP synthesized. The oxidation of glucose can be coupled to the synthesis of ATP. If the coupling is 50% efficient, how many molecules of ATP can be synthesized per molecule of glucose oxidized? Round your answer to the nearest whole number.
Consider the following reaction of the glycolysis pathway. Which statement is NOT true regarding this reaction? P + C-H NADH + H+ NAD+ C-0-P H-C-OH H-C-OH Glyceraldehyde- CH₂0-P 3-phosphate dehydrogenase CH₂0-P 1,3-Bisphosphoglycerate Glyceraldehyde-3- phosphate O A one-carbon compound (1C) is converted into a two-carbon compound (2C). O It requires a coenzyme. O It is a redox reaction catalyzed by the enzyme glyceraldehyde-3-phosphate dehydrogenase. O It is a phosphorylation reaction.

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