Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 8, Problem 28P
Assume that a mutation affects the gene for each of the following eukaryotic
a.
b. Some
c. Some
d. Some
e. Ribosomal
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Consider the following portion of mRNA produced by the normal order of DNA nucleotides: 5’ – CUU AAA CCA GUU – 3’ a. What is the template DNA sequence that was used to synthesize this portion of mRNA? b. What is the amino acid order produced from this mRNA? c. Write the amino acid sequence if a mutation changes CUU to CAU. Is this likely to affect protein function?
The figure shows the position of two of these mutations a and b. The nucleotides are altered in these 2 different swo-1 mutant alleles. Use the genetic table to describe any AA changes.Name the type of mutation and describe its effect on swo-1 mRNA and protein for each of the mutations.
3. The swo-1 a mutation (insertion between C and G).
4. The swo-1 b mutation (C-to-T mutation for indicated C).
5. The swo-1 a mutation leads to worms with more body wall muscle, whereas worms with the swo-1 b mutation are not able to move. Based on these phenotypes and the findings from questions 3 and 4, describe the role thewild-type version of this protein plays in muscle function.
A point mutation is a mutation that arises when one nucleotide in the genetic
sequence is substituted, added or deleted.
Two possible point mutations are given below:
Mutation A. Lysine is substituted for Leucine
Mutation B: Serine is substituted for Threonine
Which mutation is likely to be more serious? E Explain
Chapter 8 Solutions
Genetic Analysis: An Integrated Approach (3rd Edition)
Ch. 8 - Prob. 1PCh. 8 - 8.2 In one to two sentences each, describe the...Ch. 8 - 8.3 Answer these questions concerning...Ch. 8 - 8.4 The diagram below shows a DNA duplex. The...Ch. 8 - The following is a portion of an mRNA sequence:...Ch. 8 - Compare and contrast the properties of DNA...Ch. 8 - The DNA sequences shown below are from the...Ch. 8 - Bacterial and eukaryotic gene transcripts can...Ch. 8 - Describe the two types of transcription...Ch. 8 - What is the role of enhancer sequences in...
Ch. 8 - Prob. 11PCh. 8 - Draw a bacterial promoter and label its consensus...Ch. 8 - For a eukaryotic gene whose transcription require...Ch. 8 - Three genes identified in the diagram as A, B and...Ch. 8 - Prob. 15PCh. 8 - 8.16 The segment of the bacterial gene involved in...Ch. 8 - Prob. 17PCh. 8 - Prob. 18PCh. 8 - 8.19 A DNA fragment from the end of the mouse...Ch. 8 - 8.20 Wild-type E. coli grow best at but can grow...Ch. 8 - A mutant strain of Salmonella bacteria carries a...Ch. 8 - 8.22 The human wild-type allele and a certain...Ch. 8 - Prob. 23PCh. 8 - A full-length eukaryotic gene is inserted into a...Ch. 8 - The accompanying illustration shows a portion of a...Ch. 8 - DNA footprint protection (described in Research...Ch. 8 - Suppose you have a 1-kb segment of cloned DNA that...Ch. 8 - Assume that a mutation affects the gene for each...Ch. 8 - 8.29 The DNA sequence below gives the first base...Ch. 8 - 8.30 Genomic DNA from a mouse is isolated,...Ch. 8 - 8.31 A portion of a human gene is isolated from...
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- Complete each of the following statements by selecting from the bank of terms below. a. tRNA b. spontaneous c. repressible d. RNA processing e. mutagen f. SNRNA g. redundancy h. universal i. promoter j. elongation There are several three nucleotide codons that code for the same amino acid. This is known as (81). A specific three nucleotide codon for a fruit fly codes for the same amino acid as that same specific three nucleotide codon for a human. This means that the genetic code is (82). The three steps of transcription are initiation, (83), and termination. The (84) region on a chromosome is the sequence of nucleotides in DNA that indicates where the RNA polymerase complex should bind to initiate transcription. In a eukaryotic cell mRNA is modified in three ways. This is known as (85). The role of (86) is to combine with protein and then bind to introns to remove them and splice the RNA together. The role of (87) is to transport amino acids to the ribosome where the anticodon loop…arrow_forwardA nonsense mutation Select one: a. results in a larger protein being produced from the mutated gene b. will lead to premature termination of translation c. is the same as a silent mutation d. will lead to the premature termination of transcriptionarrow_forwardWhy might a single base-pair mutation in eukaryotic mRNA be less serious than one in prokaryotic mRNA? a. If the mutation occurs in the 5' end of the start site, it will not affect the gene product. b. If the mutation occurs in the exon, it will not affect the gene product. c. If the mutation occurs in the splice site of a transcript with alternative splicing, only one gene product may affected. O d. If the mutation occurs in the intron or not in the splice site of a transcript with alternative splicing, it will nc affect the gene product. O e. If the mutation occurs in the 3' end of the start site, it will not affect the gene product. OLIE STIC N 1Aarrow_forward
- Are the following statements TRUE or FALSE?a. Post-transcriptional RNA processing occurs in the cytoplasm of the cell.b. A primary RNA transcript is often much longer than the mature mRNA that leaves the nucleus.c. Both ends of a pre-mRNA are modified to facilitate RNA splicing.arrow_forwardA genetic researcher notices that individuals with a particular genetic disease have a shortened version of key protein involved in the diseased biochemical pathway. Which of the following mutations is most likely to result in the premature termination of protein synthesis? A. The disease is caused by a silent mutation. B. The disease is caused by a frameshift mutation. C. The disease is caused by a missense mutation. D. The disease is caused by a nonsense mutation.arrow_forwardAssume that a mutation occurs in the gene that encodes each of the following RNA polymerases. Match the mutation with its possible effects by placing the correct letter or letters in the blanks below. There may be more than one effect for each mutated polymerase. A mutation in the gene that codes for E RNA polymerase I RNA polymerase II RNA polymerase III Possibleeffects a. tRNA is not synthesized b. Some ribosomal RNA is not synthesized c. Ribosomal RNA is not processed d. pre-mRNA is not processed e. Some mRNA molecules are not degraded f. pre-mRNA is not synthesizedarrow_forward
- You are studying a eukaryotic gene in which translation normally begins at the second AUG in the mRNA (underlined). The sequence surrounding both AUGs is CGGAUGCACAGGACAUCCUACCUACGGAGAUGA.... Predict the effects of the following mutations on the translation of this mRNA. Present the new sequence, highlight the changes in the sequence and consider the best context for translation. a. Change the first and second C to G b. Change the first and second C to G and also change the UAC codon before the second AUG to UAG.arrow_forwardA strain of bacteria possesses a temperature-sensitive mutation in the gene that encodes the rho subunit. At high temperatures, rho is not functional. When these bacteria are raised at elevated temperatures, which of the following effects would you expect to see? Explain your reasoning for accepting or rejecting each of these five options. a. Transcription does not take place. b. All RNA molecules are shorter than normal. c. All RNA molecules are longer than normal. d. Some RNA molecules are longer than normal. e. RNA is copied from both DNA strands.arrow_forwardDifferential RNA splicing may result in: a. A shift in the ratio of mRNA produced from two neighboring genes b. Inversion of exons in the mature mRNA c. Production of the same protein from two different genes d. Production of two different proteins with different properties from a single genearrow_forward
- If an MRNA is alternatively spliced, then different introns are removed from a pre-MRNA, producing transcripts that will potentially encode proteins with different primary structures. I. the MRNA is found in a bacterial cell. II. transcription and translation of the MRNA will occur simultaneously. the alternative splicing happened in the cytoplasm. IV. Ay different exons from a pre-mRNA will be spliced together. V. the different MRNAS will all have poly-A tails. VI.arrow_forwardImagine that mutations occurred in one of the inverted repeat sequences within the rho-independent terminator sequence of a bacterium. What would likely be the consequence of this mutation? Select one: a. Transcription may not be initiated at all. b. Transcription may end prematurely. c. Transcription may be delayed. d. The rho protein won't be able to bind and transcription may not be terminate. e. Transcription may not be terminated and result in much longer RNA.arrow_forwardWhich of the following statements are true about eukaryotic mRNA?a. The sigma factor is essential for the correct initiationof transcription.b. Processing of the nascent mRNA may begin beforeits transcription is complete.c. Processing takes place in the cytoplasm.d. Termination is accomplished by the use of a hairpinloop or the use of the rho factor.e. Many RNAs can be transcribed simultaneously fromone DNA templatearrow_forward
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