The preparation of the below given compound using directed aldol reactions has to be given. Concept Introduction: In directed aldol reactions, the enolate anion is prepared with one carbonyl compound by LDA (Lithium diisopropylamide). The other carbonyl compound acts as an electrophile. Both of the carbonyl compounds have α-hydrogens, but only one enolate is prepared using LDA. When unsymmetrical ketone is used, it forms less substituted enolate. LDA (Lithium diisopropylamide) is a strong base. It converts aldehydes , ketones and esters into their enolate anions.

Question

Propose a mechanism for the following reaction.

Answer 1

Question

Definition Definition Organic compounds that have a carbonyl group, C=O, as their functional group. The carbonyl group in aldehydes is placed at the end of the molecular structure, which means the C=O is attached to one hydrogen atom and an alkyl group or a benzene ring. Just like all the other homologous series in organic chemistry, the naming of aldehydes uses the suffix “-al”. The general molecular formula is C n H 2n O.

Chapter 19.9, Problem 19.17P

(a)

Interpretation Introduction

Interpretation:

The preparation of the below given compound using directed aldol reactions has to be given.

Concept Introduction:

In directed aldol reactions, the enolate anion is prepared with one carbonyl compound by LDA (Lithium diisopropylamide). The other carbonyl compound acts as an electrophile. Both of the carbonyl compounds have α-hydrogens, but only one enolate is prepared using LDA. When unsymmetrical ketone is used, it forms less substituted enolate.

LDA (Lithium diisopropylamide) is a strong base. It converts aldehydes, ketones and esters into their enolate anions.

(b)

Interpretation Introduction

Interpretation:

The preparation of the below given compound using directed aldol reactions has to be given.

Concept Introduction:

In directed aldol reactions, the enolate anion is prepared with one carbonyl compound by LDA (Lithium diisopropylamide). The other carbonyl compound acts as an electrophile. Both of the carbonyl compounds have α-hydrogens, but only one enolate is prepared using LDA. When unsymmetrical ketone is used, it forms less substituted enolate.

LDA (Lithium diisopropylamide) is a strong base. It converts aldehydes, ketones and esters into their enolate anions.

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Answer 2

Question

Definition Definition Organic compounds that have a carbonyl group, C=O, as their functional group. The carbonyl group in aldehydes is placed at the end of the molecular structure, which means the C=O is attached to one hydrogen atom and an alkyl group or a benzene ring. Just like all the other homologous series in organic chemistry, the naming of aldehydes uses the suffix “-al”. The general molecular formula is C n H 2n O.

Chapter 19.9, Problem 19.17P

(a)

Interpretation Introduction

Interpretation:

The preparation of the below given compound using directed aldol reactions has to be given.

Concept Introduction:

In directed aldol reactions, the enolate anion is prepared with one carbonyl compound by LDA (Lithium diisopropylamide). The other carbonyl compound acts as an electrophile. Both of the carbonyl compounds have α-hydrogens, but only one enolate is prepared using LDA. When unsymmetrical ketone is used, it forms less substituted enolate.

LDA (Lithium diisopropylamide) is a strong base. It converts aldehydes, ketones and esters into their enolate anions.

(b)

Interpretation Introduction

Interpretation:

The preparation of the below given compound using directed aldol reactions has to be given.

Concept Introduction:

In directed aldol reactions, the enolate anion is prepared with one carbonyl compound by LDA (Lithium diisopropylamide). The other carbonyl compound acts as an electrophile. Both of the carbonyl compounds have α-hydrogens, but only one enolate is prepared using LDA. When unsymmetrical ketone is used, it forms less substituted enolate.

LDA (Lithium diisopropylamide) is a strong base. It converts aldehydes, ketones and esters into their enolate anions.

Expert Solution & Answer

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Check out sample textbook solution

Answer 3

Question

Definition Definition Organic compounds that have a carbonyl group, C=O, as their functional group. The carbonyl group in aldehydes is placed at the end of the molecular structure, which means the C=O is attached to one hydrogen atom and an alkyl group or a benzene ring. Just like all the other homologous series in organic chemistry, the naming of aldehydes uses the suffix “-al”. The general molecular formula is C n H 2n O.

Chapter 19.9, Problem 19.17P

(a)

Interpretation Introduction

Interpretation:

The preparation of the below given compound using directed aldol reactions has to be given.

Concept Introduction:

In directed aldol reactions, the enolate anion is prepared with one carbonyl compound by LDA (Lithium diisopropylamide). The other carbonyl compound acts as an electrophile. Both of the carbonyl compounds have α-hydrogens, but only one enolate is prepared using LDA. When unsymmetrical ketone is used, it forms less substituted enolate.

LDA (Lithium diisopropylamide) is a strong base. It converts aldehydes, ketones and esters into their enolate anions.

(b)

Interpretation Introduction

Interpretation:

The preparation of the below given compound using directed aldol reactions has to be given.

Concept Introduction:

In directed aldol reactions, the enolate anion is prepared with one carbonyl compound by LDA (Lithium diisopropylamide). The other carbonyl compound acts as an electrophile. Both of the carbonyl compounds have α-hydrogens, but only one enolate is prepared using LDA. When unsymmetrical ketone is used, it forms less substituted enolate.

LDA (Lithium diisopropylamide) is a strong base. It converts aldehydes, ketones and esters into their enolate anions.

Expert Solution & Answer

Trending nowThis is a popular solution!

See solution

Check out sample textbook solution

Answer 4

Question

Definition Definition Organic compounds that have a carbonyl group, C=O, as their functional group. The carbonyl group in aldehydes is placed at the end of the molecular structure, which means the C=O is attached to one hydrogen atom and an alkyl group or a benzene ring. Just like all the other homologous series in organic chemistry, the naming of aldehydes uses the suffix “-al”. The general molecular formula is C n H 2n O.

Chapter 19.9, Problem 19.17P

(a)

Interpretation Introduction