The synthesis for gabapentin has to be proposed. Concept introduction: Aldol reaction is an addition reaction of aldehydes and ketones . Aldol reaction is a reversible reaction and occurs in presence of a strong base like sodium hydroxide. One molecule (aldehyde or ketone) acts a nucleophile and attacks the electrophilic carbon center of the other molecule to give the addition product. The product is named β -hydroxy aldehyde if two aldehydes combine and β -hydroxy ketone if two ketones combine. When two molecules of an ester undergo condensation, then it is called claisen condensation. Like in aldol reaction, in claisen condensation one molecule is a nucleophile and the other molecule is an electrophile. A claisen condensation reaction is a reversible reaction and occurs in the presence of a strong base. Esterification reaction: In an esterification reaction, carboxylic acid combines with an alcohol in presence of little concentrated sulphuric acid to produce an ester. Reduction of aldehydes and ketones: In the reduction of carbonyl compounds, carbonyl compounds act as the oxidising agent and the reducing agent will be the hydrogen gas in presence of a metal.

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Questions 4 and 5

Answer 1

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 19, Problem 19.63P

Interpretation Introduction

Interpretation:

The synthesis for gabapentin has to be proposed.

Concept introduction:

Aldol reaction is an addition reaction of aldehydes and ketones. Aldol reaction is a reversible reaction and occurs in presence of a strong base like sodium hydroxide. One molecule (aldehyde or ketone) acts a nucleophile and attacks the electrophilic carbon center of the other molecule to give the addition product. The product is named β-hydroxy aldehyde if two aldehydes combine and β-hydroxy ketone if two ketones combine.

When two molecules of an ester undergo condensation, then it is called claisen condensation. Like in aldol reaction, in claisen condensation one molecule is a nucleophile and the other molecule is an electrophile.

A claisen condensation reaction is a reversible reaction and occurs in the presence of a strong base.

Esterification reaction:

In an esterification reaction, carboxylic acid combines with an alcohol in presence of little concentrated sulphuric acid to produce an ester.

Reduction of aldehydes and ketones:

In the reduction of carbonyl compounds, carbonyl compounds act as the oxidising agent and the reducing agent will be the hydrogen gas in presence of a metal.

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Questions 4 and 5

For a titration of 40.00 mL of 0.0500 M oxalic acid H2C2O4 with 0.1000 M KOH, calculate the pH at each of the following volume of KOH used in the titration: 1) before the titration begin;2) 15 mL; 3) 20 mL; 4) 25 mL; 5) 40 mL; 6) 50 mL. Ka1 = 5.90×10^-2, Ka2 = 6.50×10^-5 for oxalic acid.

Predict the major organic product(s), if any, of the following reactions. Assume all reagents are in excess unless otherwise indicated.

Answer 2

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 19, Problem 19.63P

Interpretation Introduction

Interpretation:

The synthesis for gabapentin has to be proposed.

Concept introduction:

Aldol reaction is an addition reaction of aldehydes and ketones. Aldol reaction is a reversible reaction and occurs in presence of a strong base like sodium hydroxide. One molecule (aldehyde or ketone) acts a nucleophile and attacks the electrophilic carbon center of the other molecule to give the addition product. The product is named β-hydroxy aldehyde if two aldehydes combine and β-hydroxy ketone if two ketones combine.

When two molecules of an ester undergo condensation, then it is called claisen condensation. Like in aldol reaction, in claisen condensation one molecule is a nucleophile and the other molecule is an electrophile.

A claisen condensation reaction is a reversible reaction and occurs in the presence of a strong base.

Esterification reaction:

In an esterification reaction, carboxylic acid combines with an alcohol in presence of little concentrated sulphuric acid to produce an ester.

Reduction of aldehydes and ketones:

In the reduction of carbonyl compounds, carbonyl compounds act as the oxidising agent and the reducing agent will be the hydrogen gas in presence of a metal.

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Answer 3

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 19, Problem 19.63P

Interpretation Introduction

Interpretation:

The synthesis for gabapentin has to be proposed.

Concept introduction:

Aldol reaction is an addition reaction of aldehydes and ketones. Aldol reaction is a reversible reaction and occurs in presence of a strong base like sodium hydroxide. One molecule (aldehyde or ketone) acts a nucleophile and attacks the electrophilic carbon center of the other molecule to give the addition product. The product is named β-hydroxy aldehyde if two aldehydes combine and β-hydroxy ketone if two ketones combine.

When two molecules of an ester undergo condensation, then it is called claisen condensation. Like in aldol reaction, in claisen condensation one molecule is a nucleophile and the other molecule is an electrophile.

A claisen condensation reaction is a reversible reaction and occurs in the presence of a strong base.

Esterification reaction:

In an esterification reaction, carboxylic acid combines with an alcohol in presence of little concentrated sulphuric acid to produce an ester.

Reduction of aldehydes and ketones:

In the reduction of carbonyl compounds, carbonyl compounds act as the oxidising agent and the reducing agent will be the hydrogen gas in presence of a metal.

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Answer 4

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 19, Problem 19.63P

Interpretation Introduction