The type of reaction which converts the structure B to ibuprofen in synthesis I has to be identified. Concept introduction: Malonic ester synthesis is used to prepare carboxylic acids of the desired length. The malonic ester reacts with an alkoxide base which removes a α hydrogen atom. The anion so formed is reacted with an alkyl bromide. Th anion abstracts the alkyl group from the alkyl bromide. Acidic hydrolysis of the intermediate so formed gives α − substituted malonic acid. On heating, decarboxylation takes place which gives the desired carboxylic acid .

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Answer 1

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Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 19.9, Problem CQ

Interpretation Introduction

Interpretation:

The type of reaction which converts the structure B to ibuprofen in synthesis I has to be identified.

Concept introduction:

Malonic ester synthesis is used to prepare carboxylic acids of the desired length. The malonic ester reacts with an alkoxide base which removes a α hydrogen atom. The anion so formed is reacted with an alkyl bromide. Th anion abstracts the alkyl group from the alkyl bromide. Acidic hydrolysis of the intermediate so formed gives α−substituted malonic acid. On heating, decarboxylation takes place which gives the desired carboxylic acid.

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Answer 2

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Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 19.9, Problem CQ

Interpretation Introduction

Interpretation:

The type of reaction which converts the structure B to ibuprofen in synthesis I has to be identified.

Concept introduction:

Malonic ester synthesis is used to prepare carboxylic acids of the desired length. The malonic ester reacts with an alkoxide base which removes a α hydrogen atom. The anion so formed is reacted with an alkyl bromide. Th anion abstracts the alkyl group from the alkyl bromide. Acidic hydrolysis of the intermediate so formed gives α−substituted malonic acid. On heating, decarboxylation takes place which gives the desired carboxylic acid.

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Answer 3

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 19.9, Problem CQ

Interpretation Introduction

Interpretation:

The type of reaction which converts the structure B to ibuprofen in synthesis I has to be identified.

Concept introduction:

Malonic ester synthesis is used to prepare carboxylic acids of the desired length. The malonic ester reacts with an alkoxide base which removes a α hydrogen atom. The anion so formed is reacted with an alkyl bromide. Th anion abstracts the alkyl group from the alkyl bromide. Acidic hydrolysis of the intermediate so formed gives α−substituted malonic acid. On heating, decarboxylation takes place which gives the desired carboxylic acid.

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Answer 4

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 19.9, Problem CQ

Interpretation Introduction