Biology: Life on Earth with Physiology (11th Edition)
11th Edition
ISBN: 9780133923001
Author: Gerald Audesirk, Teresa Audesirk, Bruce E. Byers
Publisher: PEARSON
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Chapter 11, Problem 6RQ
Summary Introduction
To discuss:
Whether the traits of individuals in the pedigree showing are homozygous or heterozygous and the observation concluded from the pedigree.
Introduction:
The inheritance of traits shows patterns used for the prediction of the reappearance of the traits in the offspring. The patterns of inheritance classified based on their relation to the autosomes or sex chromosomes and with dominant and recessive inheritance patterns.
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In pedigrees, individuals are usually specified by using a Roman numeral for their generation in the chart and an Arabic number for their position (reading left to right) within that generation. If we use the letter c for the allele that causes cystic fibrosis, what are the genotypes of individuals III-3 and III-4 (the third and fourth individuals shown in generation III) in the pedigree that shows this disease?
The pedigree below shows a family with a history of an autosomal recessive genetic
disease with one individual's genotype indicated (G denotes the normal allele and g
denotes the disease-causing allele).
*
O 0
O 1/8
1/4
O 1/16
Individual 1's father is known to be heterozygous (*) and his mother is known to be
homozygous dominant. Other individuals in the pedigree may be carriers, but are not
marked. The question mark (?) indicates that you do not yet know anything about this
individual's phenotype with regard to the disease.
Part 1
What is the probability that individuals 1 and 2 will have a child (5) who is a male with the
disease (the child is unborn and the sex is not yet known)?
O 1/4
1
O 1/6
5
1/8
2
01/12
gg
3
Part 2
What is the probability that the daughter (female)(6) that individual 3 and 4 just had will have the
disease?
6
*Cystic fibrosis is a rare autosomal recessive condition. phenotypically normal man whose
father had cystic fibrosis marries a phenotypically normal woman from outside the family.²
a) Draw the pedigree as far as described.
b) If the frequency of heterozygotes in the general population is 1/50, what is the
probability that the couple's first child will have cystic fibrosis?
c) If the first child does have cystic fibrosis, what is the probability that the second child
will be normal?
Chapter 11 Solutions
Biology: Life on Earth with Physiology (11th Edition)
Ch. 11.1 - describe the relationships among chromosomes, DNA,...Ch. 11.1 - Prob. 2CYLCh. 11.2 - distinguish between self-fertilization and...Ch. 11.2 - Prob. 2CYLCh. 11.3 - Sudden Death on the court Many traits, in humans...Ch. 11.3 - describe the pattern of inheritance of a trait...Ch. 11.3 - Prob. 1TCCh. 11.3 - Prob. 2CYLCh. 11.3 - Prob. 3CYLCh. 11.4 - Prob. 1CYL
Ch. 11.4 - Prob. 1TCCh. 11.4 - Prob. 2CYLCh. 11.4 - Prob. 2TCCh. 11.4 - Prob. 3CYLCh. 11.5 - Prob. 1CSCCh. 11.5 - Prob. 1CYLCh. 11.5 - Prob. 1HYEWCh. 11.5 - Prob. 1TCCh. 11.5 - explain how polygenic inheritance and...Ch. 11.6 - describe how the patterns of inheritance differ...Ch. 11.7 - Prob. 1CYLCh. 11.7 - explain why most sex-linked traits are controlled...Ch. 11.7 - describe the pattern of inheritance of sex-linked...Ch. 11.8 - Prob. 1CSRCh. 11.8 - use pedigrees to determine the pattern of...Ch. 11.8 - Prob. 1ETCh. 11.8 - Prob. 1TCCh. 11.8 - Prob. 2CYLCh. 11.8 - Prob. 2ETCh. 11 - Prob. 1ACCh. 11 - An organism is described as Rr, with red coloring....Ch. 11 - In certain cattle, hair color can be red...Ch. 11 - Prob. 1MCCh. 11 - Define the following terms: gene, allele,...Ch. 11 - Prob. 2ACCh. 11 - Prob. 2FIBCh. 11 - Prob. 2GPCh. 11 - Prob. 2MCCh. 11 - Prob. 2RQCh. 11 - Prob. 3FIBCh. 11 - Prob. 3GPCh. 11 - Prob. 3MCCh. 11 - Prob. 3RQCh. 11 - Genes that are present on one sex chromosome but...Ch. 11 - Prob. 4GPCh. 11 - Prob. 4MCCh. 11 - Prob. 4RQCh. 11 - Prob. 5FIBCh. 11 - Prob. 5GPCh. 11 - Prob. 5MCCh. 11 - Prob. 5RQCh. 11 - Prob. 6GPCh. 11 - Prob. 6RQCh. 11 - In the couple described in Problem 6, the woman...
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- For this pedigree, give the most likely mode of inheritance, assuming that the trait is rare. For the pedigree, what is the probability that III-4 and III-5 will have a boy AND he will be affected?arrow_forwardIs this pedigree dominant or recessive. Which best defines this pedigree Autosomal or sex-linked?arrow_forwardThe following family pedigree shows individuals afflicted with a metabolic disease. Suppose the male (b) and the female (c) have 2 girls and 2 boys, indicate directly on the pedigree the symbols for these children that would be most consistent with the mode of inheritance observations in the pedigree? II II a b d e IVarrow_forward
- The three genes X, Y, and Z are linked on an autosomal chromosome in humans (X to Y is 15 cM, and Y to Z is 18 cM). If an individual that is heterozygous at all three loci (XYZ/xyz) has children with an individual that is homozygous recessive at all three loci (xyz/xyz), what is the probability that they will have a child that is phenotypically identical to either parent (X-Y-Z- or xxyyzz)? Assume there is no genetic interference to double crossover events at this site.arrow_forwardGiven the following pedigree: Is the trait autosomal or sex-linked? Is the trait dominant or recessive? Based only on the information given, what is the probability that I-2 is heterozygous? Give the genotypes of individuals II-3, II-4. What is the probability that individual III-1 is purebreeding?arrow_forwardWhat feature(s) of this pedigree indicate(s) dominant inheritance?arrow_forward
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- The pedigree below tracks the inheritance of a genetic disorder through a family's generation. Determine the probable inheritance mode for the trait shown in the affected individual (the shaded symbols) by answering the following questions. I II 2 3 4 5 7 III 2 3 6 7 8 5 (i) Based on the pedigree, Y-linked inheritance can be excluded at a glance. Give your reason. (ii) What TWO (2) other modes of inheritance can be definitely excluded? Explain your answer. Of the remaining modes of inheritance, which is the most likely? Which is less likely? Explain your answers. (ii)arrow_forwardThe pedigree above shows inheritance of inability to taste PTC (shaded individuals cannot taste it), which is caused by mutation in a single gene. What is the probability that III-3 and III-4 will have a child who is heterozygous? 1 1/3 1/9 4/9 1/4 3/4 1/2 2/3 1/16arrow_forwardThe following pedigree illustrates the inheritance of a rare neurologicaldisease. What is the most likely mode of inheritance for this disorder?Explain your reasoning.arrow_forward
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