Genetics question about COVID-19. what are the mRNA codon sequences of the 2019-dominant and 2020-dominant Spike proteins? (how did you determine the actual sequence?)
Genetics question about COVID-19. what are the mRNA codon sequences of the 2019-dominant and 2020-dominant Spike proteins? (how did you determine the actual sequence?)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Genetics question about COVID-19.
what are the mRNA codon sequences of the
2019-dominant and 2020-dominant Spike proteins?
(how did you determine the actual sequence?)
![4. Consider the now dominant variant of the SARS-CoV-2 called the D614G mutation:
(A)
(C)
Spike
Nucleocapsid
Membrane
S1 subunit
S2 subunit
Envelope
614
RNA viral genome
NTD
RBD
FP
HR1
HR2 TM CT
(B)
Binding site to ACE2
receptor in human cells
N terminal
domain
$1
Fusion
HR2
protein
S2
Transmembrane
domain and
cytoplasmic tail
Trends in Genetics
a) The mutation changes an Aspartate (D, Asp) to a Glycine (G, Gly) at nucleotide position 614
(that's why it's called the D614G mutant) in the S1 subunit of the Spike protein. Using only
the information above and a codon table, what are the mRNA codon sequences of the
2019-dominant and 2020-dominant Spike proteins? Note the figure above is not needed to
answer the question. Report in 5' to 3' orientation](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Ff8883092-7c21-41d1-9cee-3382c083d02e%2F6765353a-05f1-46c6-8ccb-8f7b94fbce11%2F50d2pd_processed.jpeg&w=3840&q=75)
Transcribed Image Text:4. Consider the now dominant variant of the SARS-CoV-2 called the D614G mutation:
(A)
(C)
Spike
Nucleocapsid
Membrane
S1 subunit
S2 subunit
Envelope
614
RNA viral genome
NTD
RBD
FP
HR1
HR2 TM CT
(B)
Binding site to ACE2
receptor in human cells
N terminal
domain
$1
Fusion
HR2
protein
S2
Transmembrane
domain and
cytoplasmic tail
Trends in Genetics
a) The mutation changes an Aspartate (D, Asp) to a Glycine (G, Gly) at nucleotide position 614
(that's why it's called the D614G mutant) in the S1 subunit of the Spike protein. Using only
the information above and a codon table, what are the mRNA codon sequences of the
2019-dominant and 2020-dominant Spike proteins? Note the figure above is not needed to
answer the question. Report in 5' to 3' orientation
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