The human CFTR gene encodes a chloride ion channel; loss of function mutations in this gene cause cystic fibrosis. A wide variety of mutations causing partial or complete loss of function of this gene are found in the human population. Which of the following mutations is most likely to result in failure of the mutant allele to be transcribed?

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Gene Interactions

When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.

Gene Expression

Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.