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8. A type of gene therapy called RNA interference (RNAI) is being investigated to treat Huntington's disease. This disease is caused by a mutation in the DNA that results in the synthesis of an altered protein that leads to nervous system defects. To treat this disease, scientists synthesize short sequences of RNA (siRNA, or small interfering RNA) that form base pairs with the mRNA that codes for the mutated protein. a. Design an siRNA that will interfere with the synthesis of the protein shown in Problem 7.

8. A type of gene therapy called RNA interference (RNAI) is being investigated to treat Huntington's disease. This disease is caused by a mutation in the DNA that results in the synthesis of an altered protein that leads to nervous system defects. To treat this disease, scientists synthesize short sequences of RNA (siRNA, or small interfering RNA) that form base pairs with the mRNA that codes for the mutated protein. a. Design an siRNA that will interfere with the synthesis of the protein shown in Problem 7.

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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answer only question 8 please

7. A portion of the nucleotide sequence from the DNA coding strand of the chick ovalbumin gene is shown. What is the partial amino acid sequence of the encoded protein? CTCAGAGTTCACCATGGGCTCCATCGGTGCAGCAAGCATGGAA-(1104 bp)-TTCTTTGGCAGATGTGTTTCCCCTTAAAAAGAA
Transcribed Image Text:7. A portion of the nucleotide sequence from the DNA coding strand of the chick ovalbumin gene is shown. What is the partial amino acid sequence of the encoded protein? CTCAGAGTTCACCATGGGCTCCATCGGTGCAGCAAGCATGGAA-(1104 bp)-TTCTTTGGCAGATGTGTTTCCCCTTAAAAAGAA
8. A type of gene therapy called RNA interference (RNAI) is being investigated to treat Huntington's disease. This disease is caused by a mutation in the DNA that results in the synthesis of an altered protein that leads to nervous system defects. To treat this disease, scientists synthesize short sequences of RNA (siRNA, or small interfering RNA) that form base pairs with the mRNA that codes for the mutated protein. a. Design an siRNA that will interfere with the synthesis of the protein shown in Problem 7.
Transcribed Image Text:8. A type of gene therapy called RNA interference (RNAI) is being investigated to treat Huntington's disease. This disease is caused by a mutation in the DNA that results in the synthesis of an altered protein that leads to nervous system defects. To treat this disease, scientists synthesize short sequences of RNA (siRNA, or small interfering RNA) that form base pairs with the mRNA that codes for the mutated protein. a. Design an siRNA that will interfere with the synthesis of the protein shown in Problem 7.
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