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stop codon. C Chr1 Bace2 180 180 Exon 1 Exon 2 Exon 3 Exon 5 Exon 7 Exon 9 Exon 4 Exon 6 Exon 8 200 269 ATGCTGATC 176 CTGGCGCTCGCCCTGGAGCCC GCC GGCGGCGCCGCC CTGGCGC CGCC ATGCTGATC L 25 bp deletion Premature stop codon This means that brown bears have: shorter mRNA than black bears no transcription of exons after Exon 1

stop codon. C Chr1 Bace2 180 180 Exon 1 Exon 2 Exon 3 Exon 5 Exon 7 Exon 9 Exon 4 Exon 6 Exon 8 200 269 ATGCTGATC 176 CTGGCGCTCGCCCTGGAGCCC GCC GGCGGCGCCGCC CTGGCGC CGCC ATGCTGATC L 25 bp deletion Premature stop codon This means that brown bears have: shorter mRNA than black bears no transcription of exons after Exon 1

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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3a. The deletion found in Bace2 is in Exon 1, and codes for a premature stop codon. Chr1 Bace2 180 180 Exon 1 Exon 3 Exon 5 Exon 7 Exon 9 Exon 2 Exon 4 Exon 6 Exon 8 176 CTGGCGCTCGCCCTG CTGGCGC 25 bp deletion This means that brown bears have: 200 GCGGC GCCGCC 269 ATGCTGATC CGCC ATGCTGATC Premature stop codon shorter mRNA than black bears no transcription of exons after Exon 1 fewer amino acids made during translation no chromosome 1 3b. If the deletion had been a 24 bp deletion, do you think that the brown bear phenotype would exist? Why or why not (choose the best answer)? Yes this deletion is in an exon, it was always going to change the phenotype Yes this deletion is in the first exon, it was always going to - change the phenotype No, 25 bp deletion led to a frameshift, 24 would not have resulted in a frame shift No, a 24 bp would have led to allelic haplosufficency
Transcribed Image Text:3a. The deletion found in Bace2 is in Exon 1, and codes for a premature stop codon. Chr1 Bace2 180 180 Exon 1 Exon 3 Exon 5 Exon 7 Exon 9 Exon 2 Exon 4 Exon 6 Exon 8 176 CTGGCGCTCGCCCTG CTGGCGC 25 bp deletion This means that brown bears have: 200 GCGGC GCCGCC 269 ATGCTGATC CGCC ATGCTGATC Premature stop codon shorter mRNA than black bears no transcription of exons after Exon 1 fewer amino acids made during translation no chromosome 1 3b. If the deletion had been a 24 bp deletion, do you think that the brown bear phenotype would exist? Why or why not (choose the best answer)? Yes this deletion is in an exon, it was always going to change the phenotype Yes this deletion is in the first exon, it was always going to - change the phenotype No, 25 bp deletion led to a frameshift, 24 would not have resulted in a frame shift No, a 24 bp would have led to allelic haplosufficency
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