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1. Point mutations are changes to a single base/nucleotide in the DNA sequence of a gene. This sequence change can alter the protein made from the gene in different ways depending on the type of mutation (missense, nonsense, synonymous/silent, frameshift, and loss of stop). Below is an mRNA sequence and its translated protein. For each question, select a single base/nucleotide in the ne result in the indicated mutation (note: more than one answer may be corr one) Normal Sequence: mRNA: 5' protein: GCACGU-AUG-UAC-GGG-CAU-ACA-UGA-UCGGACC 3' Met Tyr Gly His Thr Stop Nonsense Mutation: mRNA: 5' GCACGU- Protein: Silent/Synonymous Mutation: mRNA: 5' GCACGU- Protein: position U 2nd poston UCAG Phe Phe Ser Ser Leu Leu Ser Ser Tyr Cys Cys stop Trp Leu Leu C Leu Pro Leu Pro Alle lle Thr Asn Thr Asn Val G Val Val Val Pro His Pro His Gin Gin Th Met Thr Tyr stop stop Ala Ala Lys Lys Asp Asp Arg Arg Arg Arg Ala Ala Glu Amino Acids Ser Ser Arg Arg Gly Gly Glu Gly Gly 3rd U A G G >< G

1. Point mutations are changes to a single base/nucleotide in the DNA sequence of a gene. This sequence change can alter the protein made from the gene in different ways depending on the type of mutation (missense, nonsense, synonymous/silent, frameshift, and loss of stop). Below is an mRNA sequence and its translated protein. For each question, select a single base/nucleotide in the ne result in the indicated mutation (note: more than one answer may be corr one) Normal Sequence: mRNA: 5' protein: GCACGU-AUG-UAC-GGG-CAU-ACA-UGA-UCGGACC 3' Met Tyr Gly His Thr Stop Nonsense Mutation: mRNA: 5' GCACGU- Protein: Silent/Synonymous Mutation: mRNA: 5' GCACGU- Protein: position U 2nd poston UCAG Phe Phe Ser Ser Leu Leu Ser Ser Tyr Cys Cys stop Trp Leu Leu C Leu Pro Leu Pro Alle lle Thr Asn Thr Asn Val G Val Val Val Pro His Pro His Gin Gin Th Met Thr Tyr stop stop Ala Ala Lys Lys Asp Asp Arg Arg Arg Arg Ala Ala Glu Amino Acids Ser Ser Arg Arg Gly Gly Glu Gly Gly 3rd U A G G >< G

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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1. Point mutations are changes to a single base/nucleotide in the DNA sequence of a gene. This sequence change can alter the protein made from the gene in different ways depending on the type of mutation (missense, nonsense, synonymous/silent, frameshift, and loss of stop). Below is an mRNA sequence and its translated protein. For each question, select a single base/nucleotide in the result in the indicated mutation (note: more than one answer may be corre table one) Normal Sequence: mRNA: 5' protein: GCACGU-AUG-UAC-GGG-CAU-ACA-UGA-UCGGACC 3' Met Tyr Gly His Thr Stop Nonsense Mutation: mRNA: 5' GCACGU- Protein: Silent/Synonymous Mutation: mRNA: 5' GCACGU- Protein: position U A 2nd position CA U Phe Ser Tyr Phe Ser Tyr Leu Ser stop Leu Ser stop Leu Pro His Leu Pro Leu Leu Pro Pro His Gin Gin lle Thr Asn lle Thr Asn lle Thr Met Thr Val Ala G Val Ala Val Ala Val Ala Lys Lýs 3rd Gostion Cys Cys stop Trp Arg Arg Arg Arg Ser Ser Arg Arg Gly Gly Asp Asp Glu Gly Glu Gly Amino Acids DADADADAG U C А U с А U C А U с А
Transcribed Image Text:1. Point mutations are changes to a single base/nucleotide in the DNA sequence of a gene. This sequence change can alter the protein made from the gene in different ways depending on the type of mutation (missense, nonsense, synonymous/silent, frameshift, and loss of stop). Below is an mRNA sequence and its translated protein. For each question, select a single base/nucleotide in the result in the indicated mutation (note: more than one answer may be corre table one) Normal Sequence: mRNA: 5' protein: GCACGU-AUG-UAC-GGG-CAU-ACA-UGA-UCGGACC 3' Met Tyr Gly His Thr Stop Nonsense Mutation: mRNA: 5' GCACGU- Protein: Silent/Synonymous Mutation: mRNA: 5' GCACGU- Protein: position U A 2nd position CA U Phe Ser Tyr Phe Ser Tyr Leu Ser stop Leu Ser stop Leu Pro His Leu Pro Leu Leu Pro Pro His Gin Gin lle Thr Asn lle Thr Asn lle Thr Met Thr Val Ala G Val Ala Val Ala Val Ala Lys Lýs 3rd Gostion Cys Cys stop Trp Arg Arg Arg Arg Ser Ser Arg Arg Gly Gly Asp Asp Glu Gly Glu Gly Amino Acids DADADADAG U C А U с А U C А U с А
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