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16. Consider the following original coding sequence of a gene that codes for a short 3-amino acid polypeptide: 5'-ATGTGGTCATGA-3' Using the genetic code and the amino acid table below, which of the following sequences arises from a non-conservative missense mutation in the original sequence shown above? codon U C UUU UUC UUA UUG- CUU CUC CUA U Phe (F) Leu (L) Leu (L) Second base in codon UCU UCC UCA UCG CCU CCC CCA C Ser (S) Pro (P) UAU UAC UAA UAG A Tyr (Y) STOP CAU 1 CAC CAA cla (0) His (H) G UGU UGC UGA STOI UGG Trp (W) CGU CGC CGA Cys (C) Arg (R) U C A G U C A Last b

16. Consider the following original coding sequence of a gene that codes for a short 3-amino acid polypeptide: 5'-ATGTGGTCATGA-3' Using the genetic code and the amino acid table below, which of the following sequences arises from a non-conservative missense mutation in the original sequence shown above? codon U C UUU UUC UUA UUG- CUU CUC CUA U Phe (F) Leu (L) Leu (L) Second base in codon UCU UCC UCA UCG CCU CCC CCA C Ser (S) Pro (P) UAU UAC UAA UAG A Tyr (Y) STOP CAU 1 CAC CAA cla (0) His (H) G UGU UGC UGA STOI UGG Trp (W) CGU CGC CGA Cys (C) Arg (R) U C A G U C A Last b

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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16. Consider the following original coding sequence of a gene that codes for a short 3-amino acid polypeptide: 5'-ATGTGGTCATGA-3' Using the genetic code and the amino acid table below, which of the following sequences arises from a non-conservative missense mutation in the original sequence shown above? First base in codon U A UUU UUC- UUA UUG- CUU CUC CUA CUG- AUU- ACU AUC Ile (1) ACC AUA- ACA AUG Met (M) start ACG GUU GCU GUC GCC GUA GCA GUG- GCG H₂N- U Phe (F) Leu (L) Leu (L) Nonpolar side chains; hydrophobic Val (V) Side chain (R group) H H₂N-C-C-0- HO Glycine (Gly or G) CH₂ H₂N*- CH₂ CH₂ H O Methionine (Met or M) Polar side chains; hydrophilic 0 CH₂ Second base in codon H O Aspartic acid (Asp or D) UCU UCC UCA UCG CCU CCC CCA CCG Alanine (Ala or A) OH CH₂ H₂N-C C 0 H₂N-C C 0 H O Serine (Ser or S) H O Threonine (Thr or T) Electrically charged side chains; hydrophilic OH CH3 CH -0- H₂N+- Acidic (negatively charged) CH₂ H₂N-C-C-O HO C Ser (S) Pro (P) CH₂ CH₂ Thr (T) CH₂ H₂N-C Ala (A) Phenylalanine (Phe or F) O -C-0 H O Glutamic acid (Glu or E) H₂N+ C SH CH₂ -0 A. 5'-ATGTGGTCTTGA-3' B. 5'-ATGTGATCATGA-3' C. 5'-ATGTGGACATGA-3' D. 5'-ATGGGGTCATGA-3' E. 5'-ATGTGGGCATGA-3' HO Cysteine (Cys or C) UAU UAC UAA UAG- AAU AAC AAA AAG H₂N+- CAU CAC CAA 1 CAG GAU GAC GAA GAG Valine (Val or V) с -0- H₂N- NH₂ CH₂ CH₂ CH₂ CH₂ Tyr (Y) H O Lysine (Lys or K) STOP CH3 CH3 CH H₂N-C-C-0- HO A His (H) Gln (Q) Asn (N) Lys (K) Asp (D) Glu (E) CH, H₂N-C O OH CH₂ -0 CH3 CH3 CH CH₂ H₂N-C-C-0- HO H O Tryptophan (Trp or W) H O Tyrosine (Tyr or Y) NH Leucine (Leu or L) 0 0 UGU UGC UGA STOP UGG Trp (W) CGU CGC CGA CGG AGU AGC AGA AGG GGU- GGC GGA GGG CH₂ H₂N-C CH₂ T CH₂ CH₂ H₂N-C- NH,0 Basic (positively charged) NH₂ CNH, NH HO Arginine (Arg or R) G Cys (C) Arg (R) Ser (S) Arg (R) H O Asparagine (Asn or N) Gly (G) H₂C H₂N+ CH3 CH₂ 0 CH₂ CH₂ H 0 Proline (Pro or P) H₂C-CH H₂N-C-C-0 HO Isoleucine (lle or I) -NH+ NH H₂N-C 0 NH, HO Histidine (His or H) CH₂ -0- H₂N+ C -C-0 U C A G U C A G U C A GUC A G CH₂ CH₂ 0 H Glutamine (Gin or Q) O Last base in codon
Transcribed Image Text:16. Consider the following original coding sequence of a gene that codes for a short 3-amino acid polypeptide: 5'-ATGTGGTCATGA-3' Using the genetic code and the amino acid table below, which of the following sequences arises from a non-conservative missense mutation in the original sequence shown above? First base in codon U A UUU UUC- UUA UUG- CUU CUC CUA CUG- AUU- ACU AUC Ile (1) ACC AUA- ACA AUG Met (M) start ACG GUU GCU GUC GCC GUA GCA GUG- GCG H₂N- U Phe (F) Leu (L) Leu (L) Nonpolar side chains; hydrophobic Val (V) Side chain (R group) H H₂N-C-C-0- HO Glycine (Gly or G) CH₂ H₂N*- CH₂ CH₂ H O Methionine (Met or M) Polar side chains; hydrophilic 0 CH₂ Second base in codon H O Aspartic acid (Asp or D) UCU UCC UCA UCG CCU CCC CCA CCG Alanine (Ala or A) OH CH₂ H₂N-C C 0 H₂N-C C 0 H O Serine (Ser or S) H O Threonine (Thr or T) Electrically charged side chains; hydrophilic OH CH3 CH -0- H₂N+- Acidic (negatively charged) CH₂ H₂N-C-C-O HO C Ser (S) Pro (P) CH₂ CH₂ Thr (T) CH₂ H₂N-C Ala (A) Phenylalanine (Phe or F) O -C-0 H O Glutamic acid (Glu or E) H₂N+ C SH CH₂ -0 A. 5'-ATGTGGTCTTGA-3' B. 5'-ATGTGATCATGA-3' C. 5'-ATGTGGACATGA-3' D. 5'-ATGGGGTCATGA-3' E. 5'-ATGTGGGCATGA-3' HO Cysteine (Cys or C) UAU UAC UAA UAG- AAU AAC AAA AAG H₂N+- CAU CAC CAA 1 CAG GAU GAC GAA GAG Valine (Val or V) с -0- H₂N- NH₂ CH₂ CH₂ CH₂ CH₂ Tyr (Y) H O Lysine (Lys or K) STOP CH3 CH3 CH H₂N-C-C-0- HO A His (H) Gln (Q) Asn (N) Lys (K) Asp (D) Glu (E) CH, H₂N-C O OH CH₂ -0 CH3 CH3 CH CH₂ H₂N-C-C-0- HO H O Tryptophan (Trp or W) H O Tyrosine (Tyr or Y) NH Leucine (Leu or L) 0 0 UGU UGC UGA STOP UGG Trp (W) CGU CGC CGA CGG AGU AGC AGA AGG GGU- GGC GGA GGG CH₂ H₂N-C CH₂ T CH₂ CH₂ H₂N-C- NH,0 Basic (positively charged) NH₂ CNH, NH HO Arginine (Arg or R) G Cys (C) Arg (R) Ser (S) Arg (R) H O Asparagine (Asn or N) Gly (G) H₂C H₂N+ CH3 CH₂ 0 CH₂ CH₂ H 0 Proline (Pro or P) H₂C-CH H₂N-C-C-0 HO Isoleucine (lle or I) -NH+ NH H₂N-C 0 NH, HO Histidine (His or H) CH₂ -0- H₂N+ C -C-0 U C A G U C A G U C A GUC A G CH₂ CH₂ 0 H Glutamine (Gin or Q) O Last base in codon
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