The figure provided in in the introduction above shows adenine being deaminated to form the noncanonical nucleotide inosine. Noncanonical base pairings between TRNA and MRNA occur frequently and helped lead to the wobble hypothesis concerning the relaxed base pairing rule for the third position of an MRNA codon. With respect to adenine and inosine shown in the figure, which of the following is false?
The figure provided in in the introduction above shows adenine being deaminated to form the noncanonical nucleotide inosine. Noncanonical base pairings between TRNA and MRNA occur frequently and helped lead to the wobble hypothesis concerning the relaxed base pairing rule for the third position of an MRNA codon. With respect to adenine and inosine shown in the figure, which of the following is false?
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Transcribed Image Text:NH,
NH,"
'N
NH
tRNA specific
adenosine deaminase
Adenine
Inosine
RNA
tRNA
3rd attempt
ai See Periodic Table
The figure provided in in the introduction above shows adenine being deaminated to form the noncanonical nucleotide inosine.
Noncanonical base pairings between TRNA and MRNA occur frequently and helped lead to the wobble hypothesis concerning the
relaxed base pairing rule for the third position of an MRNA codon. With respect to adenine and inosine shown in the figure, which of the
following is false?
Choose one:
A The hydrogen-bond donor on inosine (in the orange box) is likely to form a weaker hydrogen bond than will
the hydrogen-bond donor on adenine (in the orange box) if distance and orientation are optimized for both.
O B. The functional group in the square orange box in adenine can serve as both a hydrogen-bond donor and a
hydrogen-bond acceptor.
C. The enzyme responsible for this reaction works on TRNA, and not on MRNA.
O D. The inosine on a tRNA can base-pair with adenine, cytosine, or uracil on MRNA if that MRNA nucleotide is in
the third codon position, the "wobble" position.
orur
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