Biochemistry: The Molecular Basis of Life
Biochemistry: The Molecular Basis of Life
6th Edition
ISBN: 9780190209896
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
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Chapter 7, Problem 44TQ
Summary Introduction

To review:

The structural feature ofglucuronic acid thatincreases the solubility of steroid when attached to it.

Introduction:

Glucuronic acid is the monosaccharide derivative of glucose. The CH2OH terminal of glucose molecule undergoes oxidation, which results in the formation of glucuronic acid. The steroid is a lipid-soluble molecule derived from cholesterol. Steroids combine withglucuronic acid to increase its solubility in water.

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Two tetrapeptides were isolated from a possum's sweat glands. These peptides were sequenced using Edman degradation and the following 2 sequences were obtained: Gly-Asp-Ala-Leu  Gly-Asp-Asp-Leu  Can you please help show the titration curve for both of these peptides and calculate the PI?
Two tetrapeptides were isolated from a possum's sweat glands. These peptides were sequenced using Edman degradation and the following 2 sequences were obtained: Gly-Asp-Ala-Leu  Gly-Asp-Asp-Leu  What is the structure of the PTH derivative produced during the last round of amino acid sequencing?
What is the primary sequence of this undecapeptide? Also,   if x-ray crystallography shows a highly stable hairpin turn within the polypeptide, what about the primary sequence explains this structural feature?
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