Genetic Analysis: An Integrated Approach (3rd Edition)
Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 5, Problem 31P

A genetic study of an early onset form of heart disease identdies 10 families containing members with the condition. No clear dominant or recessive pattern of inheritance is evident, but an analysis of SNP markers for five families’ iletects a strong association with a marker sat chromosome 12 and genetic linkage analysis for the marker produces a lod score of 2.2.

a. What do the association and lad score results suggest about this genetic marker?

b. What next step do you recommend for this genetic analysis?

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Genetic Analysis: An Integrated Approach (3rd Edition)

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