Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Textbook Question
Chapter 5, Problem 8P
Gene G recombines with gene T at a frequency of
Assuming any desired genotype is available, propose a genetic cross whose result could be used to determine which of the proposed genetic maps is correct.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
The drug ivacaftor has recently been developed totreat cystic fibrosis in children with the rare G551Dmutant allele of CFTR.a. Do you think that ivacaftor would be effective onlyin patients homozygous for the G551D mutation,or might it work as well in compound heterozygotes in which one copy of chromosome 7 hadG551D and the other copy a different allele ofCFTR, such as the more prevalent allele ΔF508?(The protein encoded by G551D folds up properlyand inserts into the cell membrane, but is inefficient in chloride ion transport. Ivacaftor increasesthe efficiency of G551D’s ion transport. TheΔF508 protein does not fold up properly and therefore does not get inserted into the cell membrane.)b. Why do you think ivacaftor would be more effectivein children than in older cystic fibrosis patients?c. The scientists who developed ivacaftor had a modelfor cystic fibrosis: a line of cells that grow in culture and that are homozygous for G551D. Thesecells accumulate mucus at their surfaces that…
A Neurospora cross was made between a strain that carried the mating-type allele A and the mutant allele arg-1and another strain that carried the mating-type allele aand the wild-type allele for arg-1 (+). Four hundred linear octads were isolated, and they fell into the sevenclasses given in the table below. (For simplicity, they areshown as tetrads.)a. Deduce the linkage arrangement of the mating-typelocus and the arg-1 locus. Include the centromere orcentromeres on any map that you draw. Label all intervalsin map units.b. Diagram the meiotic divisions that led to class 6. Labelclearly
Consider two maize plants:a. Genotype C/c m ; Ac/Ac+, where cm is an unstable allele caused by a Ds insertionb. Genotype C/c m, where cm is an unstable allele caused by Ac insertionWhat phenotypes would be produced and in what proportions when (1) each plant is crossed with a basepair-substitution mutant c/c and (2) the plant in part a is crossed with the plant in part b? Assume that Ac and c are unlinked, that the chromosome-breakage frequency is negligible, and that mutant c /C is Ac+.
Chapter 5 Solutions
Genetic Analysis: An Integrated Approach (3rd Edition)
Ch. 5 - For parts a, b, and c, draw a diagram illustrating...Ch. 5 - 5.2 In a diploid species of plant, the genes for...Ch. 5 - A pure-breeding tall plant producing oval fruit as...Ch. 5 - 5.4 Genes E and H are syntenic in an experimental...Ch. 5 - In tomato plants, purple leaf color is controlled...Ch. 5 - 5.6 In Drosophila, the map positions of genes are...Ch. 5 - 5.7 Genes A, B, and C are linked on a chromosome...Ch. 5 - Gene G recombines with gene T at a frequency of...Ch. 5 - Genes A, B, C, D, and E are linked on a...Ch. 5 - Syntenic genes can assort independently. Explain...
Ch. 5 - 5.11 The recombination frequency between linked...Ch. 5 - On the DrosophilaX chromosome, the dominant allele...Ch. 5 - Researchers cross a corn plant that is pure -...Ch. 5 - 5.14 syndrome is an autosomal disorder affecting...Ch. 5 - 5.15 Three dominant traits of corn seedlings,...Ch. 5 - 5.16 In a diploid plant species, an with the...Ch. 5 - Prob. 17PCh. 5 - The Rh blood group in humans is determined by a...Ch. 5 - 5.19 Genetic linkage mapping for a large number of...Ch. 5 - 5.20 with the genotype form tetrads in the...Ch. 5 -
Gene and gene are genetically linked. Answer...Ch. 5 -
T. H. Morgan’s data on eye color and wing form,...Ch. 5 - Prob. 23PCh. 5 -
The boss in your laboratory has just heard of a...Ch. 5 - In rabbits, chocolate-colored fur (w+) is dominant...Ch. 5 - Prob. 26PCh. 5 - 5.27 In tomatoes, the allele for tall plant height...Ch. 5 - 5.28 Neurofibromatosis is an autosomal dominant...Ch. 5 - A 2006 genetic study of a large American family...Ch. 5 - 5.30 A experiment examining potential genetic...Ch. 5 - A genetic study of an early onset form of heart...Ch. 5 - In experiments published in 1918 that sought to...Ch. 5 - DNA sequence for 10 individuals are Identify the...Ch. 5 - 5.34 The accompanying pedigree below shows a...Ch. 5 - 5.35 Based on previous family studies, an...Ch. 5 - Divide a clean sheet of paper into four quadrant...Ch. 5 - 5.37 For six genes known to be linked on chromosme...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Consider two loci A and B that are 30 cM apart on chromosome 1 in the fruit fly. A paracentric inversion is found to span about half of the distance between these loci, but not include either A or B. What is the approximate recombination frequency expected for these loci in … flies that are heterozygous for this inversion? RF(A-B) for heterozygous flies is … flies that are homozygous for this inversion? RF(A-B) for homozygous flies is …arrow_forwardIn a cross in Drosophila, a female heterozygous for the autosomallylinked genes a, b, c, d, and e (abcde/ + + + + +) was testcrossedwith a male homozygous for all recessive alleles (abcde/abcde).Even though the distance between each of the loci was at least3 map units, only four phenotypes were recovered, yielding thefollowing data: Phenotype No. of Flies+ + + + + 440a b c d e 460+ + + + e 48a b c d + 52 Total = 1000 Why are many expected crossover phenotypes missing? Can anyof these loci be mapped from the data given here? If so, determinemap distances.arrow_forwardIn com, male sterility is controlled by maternal cytoplasmic elements. However, the presence of a nuclear fertility restorer gene (F_) restores fertility to male sterile lines. a. What are the crosses male sterile female x FF male? Give the genotypes and phenotypes of the offspring in each cross. Explain.arrow_forward
- Multiple crosses were made between true-breeding lines of black and yellow Labrador retrievers. All the F1 progeny were yellow. When these progeny were intercrossed, they produced an F2 consisting of 121 yellow, 9 black and 30 chocolate. What epistatic ratio and what kind of epistasis is approximated in the F2? Propose a biochemical pathway for coat color in Labrador retrievers based on the type of epistasis. Correlate each genotype with the phenotype that would occur in your pathway. Also show the frequency of each genotype. A-B- A-bb aaB- aabbarrow_forwardDeduce the phenotypic proportions in the progeny of thefollowing crosses of autotetraploids in which the a+/a locus is very close to the centromere. (Assume that the fourhomologous chromosomes of any one type pair randomly two by two and that only one copy of the a+ allele isnecessary for the wild-type phenotype.)a. a+/a+/a/a × a/a/a /ab. a+/a/a /a × a/a/a/ac. a+/a/a /a × a+/a/a /ad. a+/a+/a /a × a+/a/a /aarrow_forwardConsider a maize plant: Genotype C/cm ; Ac/Ac+ where cm is an unstable colorless allele caused by Ds insertion. What phenotypic ratios would be produced and in what proportions when this plant is crossed with a mutant c/c Ac+/Ac+? Assume that the Ac and c loci are unlinked, that the chromosome-breakage frequency is negligible, and the C allele encodes pigment production.arrow_forward
- Please label the tetrad type in the table as PD (parental ditype), NPD (non parental ditype) or T (tetratype) and answer the following questions a) Are the genes linked? Please explain SPECIFICALLY how you can distinguish between linked and unlinked genes in this instance. b) If the two genes are linked, calculate the % recombination between ser and thr. Show the formula used, as well as all of your calculations. c) Draw a single map illustrating the arrangement of the two genes on the chromosome with respect to each other and to the centromere of the chromosome. Make sure to map ALL three distancesarrow_forwardIn the fungus Neurospora, a strain that is auxotrophic for thiamine (mutant allele t) was crossed with a strain that isauxotrophic for methionine (mutant allele m). Linear asci were isolated and classified into the following groups: a. Determine the linkage relations of these two genes to their centromere(s) and to each other. Specify distances in map units. b. Draw a diagram to show the origin of the ascus type with only one single representative (second from right).arrow_forwardIn dogs, three STRP loci are linked on the long arm of the X chromosome (in the order centromere-A-B-C-telomere). In the pedigree shown below, each individual was genotyped for the 3 markersand bands identified on a gel are shown beneath each individual.a. Why do males always have just one allele at each locus? Why do females sometimes have oneand sometimes have two?b. Which individuals have recombinant haplotypes?c. For each recombinant individual in generation III, identify where the recombination events tookplace (between which loci AND in which parent).d. Draw a map showing the genetic distances between the three loci, based on the informationyou havearrow_forward
- A pair of paralogous repeats, A and B, have 96% sequence similarity and therefore can promote non-allelic homologous recombination (NAHR). They exist in four possible arrangements in a genome, illustrated below as arrangements 1 – 4. What is the result of NAHR between repeats A and B in arrangement 1? A.Translocation between chromosomes 1 and 2 resulting in monocentric chromosomes B.Deletion or duplication of the region between A and B C.Translocation between chromosomes 1 and 2 resulting in acentric and dicentric chromosomes D.Inversion of the region between A and Barrow_forwardPlease find the attachmentarrow_forwardstion 6 of 18 Suppose that a geneticist discovers a new mutation in Drosophila melanogaster that causes the flies to shake and quiver. She calls this mutation quiver, qu, and determines that it is due to an autosomal recessive gene. She wants to determine whether the gene encoding quiver is linked to the recessive gene for vestigial wings, vg. She crosses a fly homozygous for quiver and vestigial traits with a fly homozygous for the wild-type traits, and then uses the resulting F, females in a testcross. She obtains the flies from this testcross. Phenotype Number of flies vg* qu+ 230 vg qu 224 vg qut vg* qu 97 99 Test the hypothesis that the genes quiver and vestigial assort independently by calculating the chi-squared, X², for this hypothesis. Provide the X2 to one decimal place. X2 = Does the X value support the hypothesis that the quiver and vestigial genes assort independently? Why or why not? the partial table of critical values for X2 calculations to test this hypothesis.arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY