Concept explainers
The
a. From these data, can you conclude that Rh and
b. What is
c. Over what range of w do lod scores indicate significantevidence in favor of genetic linkage?
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Genetic Analysis: An Integrated Approach (3rd Edition)
- Achondroplasia is a rare dominant autosomal defect resulting in dwarfism. The unaffected brother of an individual with achondroplasia is seeking counsel on the likelihood of his being a carrier of the mutant allele. What is the probability that the unaffected client is carrying the achondroplasia allele?arrow_forwardState whether each of the following genetic defects is inherited as an autosomal recessive, autosomal dominant, or X-linked recessive trait: phenylketonuria (PKU), sickle cell anemia, cystic fibrosis, Tay-Sachs disease, Huntingtons disease, and hemophilia A.arrow_forwardThe mother of a family with 10 children has blood typeRh+. She also has a very rare condition (elliptocytosis,phenotype E) that causes red blood cells to be oval rather than round in shape but that produces no adverseclinical effects. The father is Rh− (lacks the Rh+ antigen)and has normal red blood cells (phenotype e). The children are 1 Rh+ e, 4 Rh+ E, and 5 Rh− e. Information isavailable on the mother’s parents, who are Rh+ E andRh− e. One of the 10 children (who is Rh+ E) marriessomeone who is Rh+ e, and they have an Rh+ E child.a. Draw the pedigree of this whole family.b. Is the pedigree in agreement with the hypothesisthat the Rh+ allele is dominant and Rh− is recessive?c. What is the mechanism of transmission ofelliptocytosis?d. Could the genes governing the E and Rh phenotypesbe on the same chromosome? If so, estimate the mapdistance between them, and comment on your resultarrow_forward
- autosomal recessive allele (not sex-linked). Omplete the following monohybrid crosses for different types neritance pattefh autosomal dominant, sex linked recessive, and dominant inheritance. Inheritance of autosomal recessive traits Female parent phenolype: Example: Albinism Albinism (lack of pigment in hair, eyes and skin) is inherited as an Male parent phenatype: Using the codes: PP Pp (normal) (albino) la) Enter the parent phenotypes and complete the Punnett square for a cross between two carrier genotypes. A Give the ratios for the phenotypes from this cross. Pp (carrier) eggs sperm Phenotype ratios: Inheritance of autosomal dominant traits Example: Woolly hair Woolly hair is inherited as an autosomal dominant allele. Each affected individual will have at least one affected parent. Using the codes: WW (woolly hair) Female parent phenotype: Male parent phenotype: Ww (woolly hair, heterozygous) W w (normal hair) (a) Enter the parent phenotypes and complete the Punnett square for a…arrow_forward(x-linked genes q8) Please answer this question for mearrow_forwardDoes this individual display any genetic disorders?arrow_forward
- A couple are both phenotypically normal but their son suffers from hemophilla, a sex linked recessive disorder. What fraction of their children are likely to suffer from hemophilia. what fraction are likely to be carriers.arrow_forwardDescribe the genetics of Hemophilia A O Disease-causing alleles are full or partial loss-of-function alleles Late age of onset Recessive Rare O X-linked Autosomal Dominantarrow_forwardThe gene that is responsible for producing clotting factor VIII is located on the X chromosome. A recessive mutation in this gene causes the most common type of hemophilia; it is known as hemophilia A. If this gene is mutated in the hemophilia, but it will always cause this type of hemophilia if mutated in the This is because have two X chromosomes; since this is a recessive mutation, more than likely the other X chromosome has the normal gene. View Available Hint(s) Omale: female; females O female: male: females O male; female, males. O child; adult; adults it sometimes causes this type ofarrow_forward
- In humans, the Rh factor genetic information is inherited from our parents, but it is inherited independently of the ABO blood type alleles. In humans, Rh+ individuals have the Rh antigen on their red blood cells, while Rh- individuals do not. There are two different alleles for the Rh factor known as Rh+ and rh. Assume that a dominant gene Rh produces the Rh+ phenotype, and that the recessive rh allele produces the Rh- phenotype. In a population that is in Hardy-Weinberg equilibrium, if 160 out of 200 individuals are Rh+, calculate the frequencies of both alleles.arrow_forwardRhesus factor is a protein found onlthe surface of the red blood cells. Having Rhesus factor (Rh+) is dominant over having none (Rh-). What cross could result to Rhesus factor incompatibility? Rh- mother x Rh+ father O Rh- father x Rhesus+ mother O Rh- mother x Rh- father O Rh+ father x Rh+ motherarrow_forwardHow many males have hemopilia? (refer to image).arrow_forward
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