Chapter 5, Problem 18P

The $\text{Rh}$ blood group in humans is determined by a geneon chromosome $\text{1}$. A dominant allele produces $\text{Rh+}$ bloodtype, and a recessive allele generates $\text{Rh-}$. $\text{Elliptocytosis}$ isan autosomal dominant disorder that produces abnormallyshaped red blood cells that have a short life span resultingin hereditary anemia. A large family with $\text{elliptocytosis}$ istested for genetic linkage of $\text{Rh}$ blood group and the disease. The lod score data below are obtained for the family.

a. From these data, can you conclude that Rh and $\text{elliptocytosisloci}$ are genetically linked in this family? Why or why not?

b. What is $\text{Z}$ max for this family?

c. Over what range of w do lod scores indicate significantevidence in favor of genetic linkage?