Genetic Analysis: An Integrated Approach (3rd Edition)
Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 5, Problem 24P

The boss in your laboratory has just heard of a proposal by another laboratory that genes for eye color and the length of body bristles may be linked in Drosophila. Your lab has numerous pure-breeding stocks of Drosophila that could be used to verify of refute genetic linkage. In Drosophila, red eyes ( c + ) are dominant to brown eyes ( c ) , and long bristles ( d + ) are dominant to short bristles ( d ) . Your lab boss asks you to design an experiment to test the genetic linkage of eye color and bristle-length genes, and to begin by crossing a pure-breeding line homozygous for red eyes and short bristles to a pure-breeding line that has brown eyes and long bristles.

a. Give the genotypes of the pure-breeding parental-files, and the genotype ( s ) and phenotype(s) of the F 1 progeny they produce.

b. In your experimental design, what are the genotype and phenotype of the line you propose to cross to the F1 to obtain the most useful information about genetic linkage between the eye color and bristle-length genes? Explain why you make this choice.

c. Assume the eye color and bristle-length genes are separated by 28 m .u . What are the approximate frequencies of phenotypes expected from the cross you proposed in part ( b ) ?

d. How would the results of the cross differ if the genes are not linked?

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Female Drosophila heterozygous for three recessive mutations e (ebony body), st (scarlet eyes), and ss (spineless bristles) were testcrossed, and the following progeny were obtained: Phenotype Number wild-type 67 ebony 8 ebony, scarlet 68 ebony, spineless 347 ebony, scarlet, spineless 78 scarlet 368 scarlet, spineless 10 spineless 54 (a) What indicates that the genes are linked? (b) What was the genotype of the original heterozygous females? (c) What is the order of the genes? (d) What is the map distance between e and st? (e) Between e and ss? (f) What is the coefficient of coincidence? (g) Diagram the crosses in this experiment.
In Drosophila, a female with three recessive traits, miniature wings, (m), ebony body (e) and rough eyes (r) were crossed with true-breeding wild-type males. In the F1, all offspring had wild-type phenotypes. F1 offspring were testcrossed to miniature, ebony, rough individuals and 1000 offspring were counted, shown in the table below. Determine the genotypes of the P1 and F1 parents. Determine the sequence of the three genes and the map distance between them. Are there more or fewer double crossovers than expected? Calculate the interference. Phenotype Offspring m e r 310 + + + 284 + e r 150 m + + 156 m + r 45 + e + 32 m e + 8 + + r 15 Total 1000
Consider the following three autosomal recessive mutations in Drosophila:vestigial wings (v); wild type is long (v+)black body color (b); wildtype is gray (b+)plum eyes (p); wildtype is red (p+)A vestigal, gray, red female (homozygous for all three genes) is crossed with a long wing, black, plum male (homozygous for all three genes). The F1 female progeny are mated with triple homozygous recessive males. Here is the phenotypic data for the F2 progeny:vestigal; gray; red 580long wings; black; plum 592vestigal; black; red 45long; gray; plum 40vestigal; black; plum 89long; gray; red 94vestigal; gray; plum 3long; black; red 5A total of 1448 progeny were counted.Which one of the following values is the approximate distance between the plum eye color and black body color loci?

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Genetic Analysis: An Integrated Approach (3rd Edition)

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