Chapter 5, Problem 35P

Based on previous family studies, an autosomal recessive disease with alleles A and a is suspected to be linked to an RFLP marker. The RFLP marker has four alleles, $\text{R1,R2,R3, and R4}$. The accompanying pedigree shows a three generation family in which the disease is present. The gel shows the RFLP alleles for each family member directly below the pedigree symbol for that person. After determining the genotypes for the RFLP and disease gene for each family members, answer the following questions.

a. What is the most likely arrangement of synthesis alleles for the RFLP and the disease gene in $\text{I-1}$ and $\text{I-2}$?

b. Is there any evidence of recombination in this pedigree? If so, identify the recombinant individuals and illustrate the recombination that has occurred.

c. Based on your analysis, what is the recombination frequency in this family? Explain how you obtained your answer.