Fundamentals of General, Organic, and Biological Chemistry (8th Edition)
8th Edition
ISBN: 9780134015187
Author: John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher: PEARSON
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Chapter 21, Problem 21.23UKC
Interpretation Introduction
Interpretation:
The acceptor of hydrogen ions and hydride ions in citric acid cycle should be given.
Concept Introduction:
Citric Acid Cycle: It involves 8 series reaction which converts acetyl group present in acetyl coenzyme A into 2
Figure 1
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Since no molecular oxygen participates in the citric acid cycle, the steps in which acetyl groups are oxidized to CO2 involve removal of hydride ions and hydrogen ions. What is the acceptor of hydride ions? What is the acceptor of hydrogen ions?
Which reaction in the citric acid cycle is most analogous to the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate? What kind of enzymebound intermediate is formed in both reactions?
There are eight chemical reactions that occur in the citric acid cycle process. The reactions of the citric acid cycle are shown in the figure below.
acetyl-coenzyme A
0
CH₂-C-CoA
HO-CH
Reaction 7
O
malate
CH₂
CH
||
CH
fumarate
FADH₂
Reaction 6
FAD
H+ + NADH
NAD+
1,0
H₂C
CH₂
CH₂
Reaction 8
succinate
ADP
0=C
GTP
CH₂
oxaloacetate
Reaction 5
H-COA
GDP
ATP
H₂O
Reaction 1
C
Reactions of the
Citric Acid Cycle
CH₂
CH₂
H-COA
0=C
1
CoA
succinyl-CoA
H+
HO-C
Reaction
CO₂
с
CH₂
NADH
CH₂
citrate
Reaction 2
H-COA
Reaction 3
CO₂
I
CH₂
T
CH₂
0=C
NAD+
HO–CH
a-ketoglutarate
CH,
CH
isocitrate
NAD+
H+ + NADH
In chapters 9 and 10, you were introduced to several classes of organic reactions. These classes include esterification, decarboxylation, hydration
reactions, dehydration of alcohols, oxidation of alcohols, oxidation of aldehydes, reduction of aldehydes, and reduction of ketones. Find at least one of
these reaction classes in the citric acid cycle. List the reaction number and the reaction. Write a…
Chapter 21 Solutions
Fundamentals of General, Organic, and Biological Chemistry (8th Edition)
Ch. 21.1 - In a cell, glucose can be oxidized via metabolic...Ch. 21.1 - Prob. 21.2KCPCh. 21.1 - Prob. 21.1CIAPCh. 21.1 - Prob. 21.2CIAPCh. 21.1 - Prob. 21.3CIAPCh. 21.1 - Prob. 21.4CIAPCh. 21.3 - Prob. 21.3PCh. 21.4 - Prob. 21.4PCh. 21.4 - Prob. 21.5PCh. 21.4 - Prob. 21.5CIAP
Ch. 21.4 - How does a cell disarm each of the ROS in CIA...Ch. 21.5 - One of the steps in lipid metabolism is the...Ch. 21.5 - Prob. 21.7PCh. 21.5 - Prob. 21.7CIAPCh. 21.5 - Prob. 21.8CIAPCh. 21.5 - Prob. 21.9CIAPCh. 21.5 - Prob. 21.10CIAPCh. 21.5 - Prob. 21.8PCh. 21.6 - Prob. 21.9PCh. 21.6 - Prob. 21.10PCh. 21.7 - Prob. 21.11PCh. 21.7 - Prob. 21.13PCh. 21.7 - Identify the participants in the citric acid cycle...Ch. 21.7 - Prob. 21.15PCh. 21.7 - Prob. 21.16KCPCh. 21.8 - Within the mitochondrion, is the pH higher in the...Ch. 21.8 - Prob. 21.18PCh. 21.8 - Prob. 21.19KCPCh. 21.8 - Prob. 21.11CIAPCh. 21.8 - Prob. 21.12CIAPCh. 21.8 - Prob. 21.13CIAPCh. 21 - Prob. 21.20UKCCh. 21 - Each of these reactions is involved in one of the...Ch. 21 - Prob. 21.22UKCCh. 21 - Prob. 21.23UKCCh. 21 - The reaction that follows is catalyzed by...Ch. 21 - Prob. 21.25UKCCh. 21 - The electron-transport chain uses several...Ch. 21 - Prob. 21.27APCh. 21 - What is the difference between an endergonic...Ch. 21 - Prob. 21.29APCh. 21 - Prob. 21.30APCh. 21 - Prob. 21.31APCh. 21 - Prob. 21.32APCh. 21 - Which of the following organisms are prokaryotes,...Ch. 21 - Label each of the following as a characteristic of...Ch. 21 - Prob. 21.35APCh. 21 - Prob. 21.36APCh. 21 - Describe in general terms the structural makeup of...Ch. 21 - Prob. 21.38APCh. 21 - Prob. 21.39APCh. 21 - Prob. 21.40APCh. 21 - Prob. 21.41APCh. 21 - Prob. 21.42APCh. 21 - Prob. 21.43APCh. 21 - Prob. 21.44APCh. 21 - What does it mean when we say that two reactions...Ch. 21 - Prob. 21.46APCh. 21 - Prob. 21.47APCh. 21 - Prob. 21.48APCh. 21 - Prob. 21.49APCh. 21 - Prob. 21.50APCh. 21 - Prob. 21.51APCh. 21 - Prob. 21.52APCh. 21 - Prob. 21.53APCh. 21 - Prob. 21.54APCh. 21 - Prob. 21.55APCh. 21 - Prob. 21.56APCh. 21 - Prob. 21.57APCh. 21 - Prob. 21.58APCh. 21 - Prob. 21.59APCh. 21 - Prob. 21.60APCh. 21 - Prob. 21.61APCh. 21 - Prob. 21.62APCh. 21 - Prob. 21.63APCh. 21 - Prob. 21.64APCh. 21 - Prob. 21.65APCh. 21 - Prob. 21.66APCh. 21 - Prob. 21.67APCh. 21 - Prob. 21.68APCh. 21 - What does the term oxidative phosphorylation mean?...Ch. 21 - Prob. 21.70APCh. 21 - Prob. 21.71APCh. 21 - Prob. 21.72APCh. 21 - Prob. 21.73APCh. 21 - Prob. 21.74APCh. 21 - Prob. 21.75APCh. 21 - Prob. 21.76APCh. 21 - Prob. 21.77CPCh. 21 - Fumarate produced in step 6 of the citric acid...Ch. 21 - With what class of enzymes are the coenzymes NAD+...Ch. 21 - Prob. 21.80CPCh. 21 - Prob. 21.81CPCh. 21 - Prob. 21.82CPCh. 21 - The mitochondrion pumps H+ from the matrix into...Ch. 21 - Prob. 21.84CPCh. 21 - Prob. 21.85CPCh. 21 - Prob. 21.86CPCh. 21 - Prob. 21.87GPCh. 21 - Prob. 21.88GPCh. 21 - Prob. 21.89GP
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- What is the net reaction of the citric acid cycle? What happens to each product? OXIDATIVE PHOSPHORYLATION: 3A) Thoroughly explain the biological significance of NADH/H* and FADH₂ and their roles in oxidative phosphorylation. 3B) Describe and diagram the general pathway of the electrons from NADH/H+ and FADH2 to 02 during the electron transport chain. 3C) What is "chemiosmotic coupling", and what is its relationship to ATP synthesis? 3D) During oxidative phosphorylation, what is oxidized and what is phosphorylated?arrow_forward|a) Explain why the citric acid cycle is considered to be the center of cellular metabolism. b) What are the substrates and products corresponding to one turn of the citric acid cycle? (no need for enzymes) c) Which steps of the citric acid cycle release CO2 as a product? Which steps produce NADH or FADH2? Which step produces GTP? d) How much ATP can be generated from glucose when the citric acid cycle is operating?arrow_forwarda) Describe the three irreversible reactions of the Citric Acid Cycle. Ensure to indicate their purpose/role, the substrates and products, the enzyme involved, and any significant features of the reaction. b) Why are these reactions considered irreversible (why can't they be reversed)? c) Using one of the reactions as an example, explain why it is important for the cell that the reaction is irreversible.arrow_forward
- In the citric acid cycle, the coenzyme NAD is required for which of the following reactions (Choose all that apply) O hydration of fumarate to malate O isomerization of citrate to isocitrate O oxidation of succinate to fumarate. O oxidation of isocitrate to the oxalosuccinate intermediate to permit beta decarboxylation of isocitrate to alpha-ketoglutarate condensation of acetyl-CoA and oxaloacetate to form citrate oxidation of malate to oxaloacetate decarboxylation of alpha-ketoglutarte to succinyl CoA O conversion of succinyl-CoA to succinatearrow_forwardWhat enzymes from the citric acid cycle that are allosterically regulated by ATP and/or NADH? What enzymes from the citric acid cycle that allosterically regulated by NAD+?arrow_forwardThe citric acid cycle is a critical sequence of reactions for energy production, which take place in the matrix of the mitochondria. The reaction cycle requires materials from the cytosol to be converted into acetyl CoA, which represents the starting point of a new cycle. Which of the following statements about acetyl CoA is true? (a) Acetyl CoA is recycled at the end of every cycle. (b) Oxaloacetate is attached to acetyl CoA to feed the citric acid cycle. (c) Triacylglycerol molecules are transported into the mitochondrial matrix and cleaved by lipases to produce acetyl CoA. (d) Oxaloacetate is converted directly into acetyl CoA to feed the citric acid cyclearrow_forward
- match the cofactor with its function in the citric acid cycle by entering the number corresponding with the function. A given function may be used more than one time or not at all. Use from the following list of functions to fill in the table below: carries O2 carries small carbon-containing molecules carries e- carries small nitrogen-containing molecules Cofactor Function NAD+/NADH FAD/FADH2 CoA thiamine biotinarrow_forwardWhich reactions of the citric acid cycle transfer energy as FADH2?arrow_forwardHow many acetyl CoA molecules are produced in one cycle of beta oxidation? How many cycles would it take to catabolize a stearic acid molecule (a fatty acid, [18:0]) into acetyl Co A units? a)How many acetyl CoA molecules would be produced? b) How many reduced nucleotides would be produced? c) If a molecule of glucose produces a net 32 ATP when completely catabolized, which do you think will produce more energy, one molecule of glucose or one molecule of stearic acid? Justify your answer.arrow_forward
- Does any step of the citric acid cycle directly produce ATP? Explain.arrow_forwarda) What is the reason for the non-oxidative phase of the pentose phosphate pathway?b) Which compound is converted into which compound in the step where sequential dehydration and hydration reactions occur in the citric acid cycle?c) Why is ammonia released in some tissues carried by binding to other molecules in the blood? Where is it transmitted in the body for its destruction? What molecule is it transferred onto there? So what molecule does it make?arrow_forwardAll the dehydrogenases of glycolysis and the citric acid cycle use NAD+ (E°' for NAD+/NADH is -0.32 V) as the electron acceptor, except succinate dehydrogenase, which uses covalently bound FAD (E°' for FAD/FADH2 is +0.050 V). Suggest why FAD is a more appropriate electron acceptor than NAD+ in the dehydrogenation of succinate, based on the E°' values of fumarate/succinate (E°' = +0.031 V)arrow_forward
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