Concept explainers
Interpretation:
The reason that supports succinate dehydrogenase is the coenzyme in the reaction of citric acid cycle which is catalyzed by
Concept Introduction:
Citric Acid Cycle: It involves 8 series reaction which converts acetyl group present in acetyl coenzyme A into 2
Coenzyme: They are non-proteins molecules which helps enzymes for catalyzing the reaction.
Flavin Adenine Dinucleotide
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Fundamentals of General, Organic, and Biological Chemistry (8th Edition)
- What enzymes from the citric acid cycle that are allosterically regulated by ATP and/or NADH? What enzymes from the citric acid cycle that allosterically regulated by NAD+?arrow_forwardHow is succinate dehydrogenase unique compared with the other enzymes in the citric acid cycle?arrow_forwardWhich reaction in the citric acid cycle is most analogous to the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate? What kind of enzymebound intermediate is formed in both reactions?arrow_forward
- Although molecular oxygen (O2) does not participate directly in any of the reactions of the citric acid cycle, the cycle operates only when O2 is present. Explain this observation.arrow_forwardThe citric acid cycle operates only when O2 is present, yet O2 is not a substrate for the cycle. Explain.arrow_forwardMalonate is a competitive inhibitor of succinate dehydrogenase. How will the concentrations of citric acid cycle intermediates change immediately after the addition of malonate? Why is malonate not a substrate for succinate dehydrogenase?arrow_forward
- What step in the citric acid cycle is inhibited by fluoroacetate treatment?arrow_forwardIf α-ketoglutarate is removed from TCA cycle and used to make glutamate, how many of each of the cofactors (not intermediates) and high energy molecules in the TCA cycle are lost? How much ATP does this equate to (NADH = 2.5 ATP, FADH2 = 1.5 ATP)?arrow_forwardWhich one of the five steps of the pyruvate dehydrogenase complex reaction is most likely to be metabolically irreversible? Explain.arrow_forward
- If glutamate were labeled with C-14 at the delta-carbon and added via transamination to the citric acid cycle to produce alpha-ketoglutarate, how long would it take for the compounds containing C-14 to be reduced by 25% (assume 10 seconds per turn of the cycle)?arrow_forwardHow many NADH and how many FADH2 molecules are formed in the citric acid cycle?arrow_forwardDoes any step of the citric acid cycle directly produce ATP? Explain.arrow_forward
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