Genetic Analysis: An Integrated Approach (2nd Edition)
2nd Edition
ISBN: 9780321948908
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Textbook Question
Chapter 12, Problem 28P
During mismatch repair, why is it necessary to distinguish between the template strand and the newly made daughter strand? Describe how this is accomplished.
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Students have asked these similar questions
Explain how mismatch repair fixes incorrectly matched base pairs.
During mismatch repair, why is it necessary to distinguish betweenthe template strand and the newly made daughter strand? How isthis accomplished?
What is/are the attributes that make nucleotide excision repair (NER) and base excision repair (BER)
similar and/or different from each other?
Select the correct response:
The NER pathway is the only one that can remove DNA lesions in the strand regardless of
their size which is followed by attaching the correct strand, then sealed by a DNA ligase.
They both use the enzyme DNA glycosylases that recognizes the damaged DNA segments
and proceed with repairing the faulty base in the strand. They differ NER only repairs purine
bases while BER repairs pyrimidine bases.
They both remove the damaged parts of the DNA where the BER pathway corrects only the
identified damaged bases which are usually non-bulky lesions. The NER pathway, on the
other hand, repairs the damage by removal of bulky DNA adducts which is a short-single
stranded DNA segment.
They both utilize the enzyme photolyase to reverse the damages created by the faulty section
of the DNA.
They both remove the damaged parts of the…
Chapter 12 Solutions
Genetic Analysis: An Integrated Approach (2nd Edition)
Ch. 12 - 11.1 Identify two general ways chemical mutagens...Ch. 12 - 11.2 Nitrous acid and (BU) alter DNA by different...Ch. 12 - 11.19 Using the adeninethymine base pair in this...Ch. 12 - The partial amino acid sequence of a wild-type...Ch. 12 - 5. Thymine is usually in its normal, common form....Ch. 12 - Ultraviolet (UV) radiation is mutagenic.
What...Ch. 12 - Researchers interested in studying mutation and...Ch. 12 - The effect of base - pair substitution mutations...Ch. 12 - Prob. 9PCh. 12 - 11.10 In numerous population studies of...
Ch. 12 - 11.11 Two different mutations are identified in a...Ch. 12 - 11.22 Many human genes are known to have homologs...Ch. 12 - 11.13 Answer the following questions concerning...Ch. 12 - Prob. 14PCh. 12 - Prob. 15PCh. 12 - Prob. 16PCh. 12 - 11.15 A sample of the bacterium is exposed to...Ch. 12 - 11.16 A strain of is identified as having a null...Ch. 12 - Define gene conversion and contrast it with gene...Ch. 12 - Prob. 20PCh. 12 - Prob. 21PCh. 12 - Prob. 22PCh. 12 - Prob. 23PCh. 12 - Prob. 24PCh. 12 - 25. If homologous recombination did not occur,...Ch. 12 - In this chapter, three features of genes or of DNA...Ch. 12 - Briefly compare the production of DNA double -...Ch. 12 - During mismatch repair, why is it necessary to...Ch. 12 - 11.27 Following the spill of a mixture of...Ch. 12 - A geneticist searching for mutations uses the...Ch. 12 - A wild - type culture of haploid yeast is exposed...Ch. 12 - A fragment of a wild - type polypeptide is...Ch. 12 - Prob. 33PCh. 12 - 11.40 Common baker’s yeast () is normally grown at...Ch. 12 - 11.41 The two gels illustrated below contain...Ch. 12 - Alkaptonuria is a human autosomal recessive...Ch. 12 - 11.33 In an experiment employing the methods of...Ch. 12 - Using your knowledge of DNA repair pathways choose...Ch. 12 - 11.35 Ataxia telangiectasia is a human inherited...Ch. 12 - 40. Two haploid strains of fungus are fused to...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- In the scenario where a single strand break occurs in the DNA replication fork: a) What would happen if RecC failed to bind to the chi site? Explain briefly and draw out the step at which recombinational DNA repair would stall. b) What would happen if RecA failed to bind DNA? Explain briefly and draw out the step at which recombinational DNA repair would stall. c) Draw the resolved product of this Holliday junction if it's cleaved in the direction of the white triangles. Is the result a heteroplex or recombinant? A Strand Invasion Ⓒ Holliday Junction A Resolvearrow_forwardWhen the mismatch repair system detects a distortion in the DNA double helix due to a mismatch, what mechanism ensures that the base on the parental strand is preserved and the base on the recently replicated strand is corrected.arrow_forwardThere are two types of excision repair, base excision repair (BER) and nucleotide excision repair (NER). Which enzymes are used in Base excision repair in E. coli?And In nucleotide excision repair, what kind of damage is repaired by this mechanism and why are cutsmade on both sides of the damaged region of DNA?arrow_forward
- Explain whether mismatch repair reduce the replication error if it is repaired without regard for which strand served as template.arrow_forwardExplain how methyl-directed mismatch repair candistinguish which strand to repair when replicationerrors occur.arrow_forwardDuring the process of transcription, the polymerase must handle several distinct polynucleotide chains: the double-stranded DNA ahead of the polymerase, the single-stranded template DNA, the nontemplate DNA strand, and the freshly-synthesized mRNA. How does the polymerase keep each of these strands--as well as the incoming ribonucleotides needed for the polymerase reaction--separate?arrow_forward
- What enzymatic features of DNA polymerase prevent it from replicating one of the DNA strands at the ends of linear chromosomes? Compared with DNA polymerase, how is telomerase different in its ability to synthesize a DNA strand? What does telomerase use as its template for the synthesis of a DNA strand? How does the use of this template result in a telomere sequence that is tandemly repetitive?arrow_forward"The mechanism does not recruit a homologous region of DNA during repair". Explain this ?arrow_forwardExplain why base excision repair, nucleotide excision repair, and mismatch repair—which all require nucleases to excise damaged DNA—require DNA ligase.arrow_forward
- A certain template DNA strand has the following nucleotide sequence: 3’-TACTCGATGCTGTGCGAT-5’ a) What would be the nucleotide sequence of the complementary nontemplate DNA strand? What is this process called and where does this occur in the eukaryotic cell? b) Take the template strand through the process of transcription. What is the resulting strand called and where does this process occur in a eukaryotic cell. c) Take the template strand through the process of translation including the location in the cell. You should finish with a polypeptide chain. You will need to use the Genetic code found in your notes/bookarrow_forwardCytosine can be deaminated to form Uracil What type of mutation is this classified as? Discuss what happens to the base-pairing properties from switching from C to U? When U is replicated in two rounds of synthesis, what substitution does this result in? Before Uracil alters the DNA during replication, what repair system can be used to correct this error? Describe how this type of DNA repair works?arrow_forwardHow does e.coli and human cells distinguish between the old and new strands for mismatch repair?arrow_forward
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