Table 1. Human D₁-Like Receptor Binding Data for Synthons" R. B C K₁ ± SEM (nM) compd R 11a H 11b H AHU B C D,R OMe а 619 ± 97.6 D,R 446 ± 25.2 DR D₁/D, D./D, D/D₂ 2300 ± 820 1.4 5.2 3.7 H H 13911.9 31.1 ± 0.462 316 ± 47.1 4.5 10 2.3 12a Me H OMe а 233±22.4 179 ± 18.1 400 ± 83.4 1.3 2.2 1.7 12b Me a H H 58.13.09 13.6±0.488 89.9 ± 6.81 4.3 6.6 1.5 13a -But H n-But Cl OMe H а H 29.8 ± 4.58 2.93 +0.316 13b "Binding inhibition values determined using HEK 293 cells transfected with hDR, hD,R, or hD and ['H]N-methylspiperone radioligand as described. 59 4.4 22.5 ± 4.86 0.363 + 0.052 322 ± 76.0 6.5.1+10.0 1.3 14 11 8.1 179 22

Table 1. Human D₁-Like Receptor Binding Data for Synthons" R. B C K₁ ± SEM (nM) compd R 11a H 11b H AHU B C D,R OMe а 619 ± 97.6 D,R 446 ± 25.2 DR D₁/D, D./D, D/D₂ 2300 ± 820 1.4 5.2 3.7 H H 13911.9 31.1 ± 0.462 316 ± 47.1 4.5 10 2.3 12a Me H OMe а 233±22.4 179 ± 18.1 400 ± 83.4 1.3 2.2 1.7 12b Me a H H 58.13.09 13.6±0.488 89.9 ± 6.81 4.3 6.6 1.5 13a -But H n-But Cl OMe H а H 29.8 ± 4.58 2.93 +0.316 13b "Binding inhibition values determined using HEK 293 cells transfected with hDR, hD,R, or hD and ['H]N-methylspiperone radioligand as described. 59 4.4 22.5 ± 4.86 0.363 + 0.052 322 ± 76.0 6.5.1+10.0 1.3 14 11 8.1 179 22

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter26: Synthesis And Degradation Of Nucleotides

Section: Chapter Questions

Problem 22P

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Using the ActiveModel for phosphofructokinase (Trypanosoma), describe the difference between the APO1, AP02, and holoenzyme conformations.
THOUGHT QUESTION Imagine we identify a gene that is directly responsible for the effects of vasopressin on male mammals, including humans-we will call it trust1-that leads to the production of a vasopressin receptor in the brain, which we will call TRUST1. There are different versions of trust1, all of which lead to different levels of the behavior associated with this neuropeptide on male behavior. Give some examples where it would be a good idea to know a particular males genotype-that is, which of the trust1 genes he has. Give an example of when you think science has gone too far and this information should not be known.
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