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Define the terms regarding immunoglobulin G: Fab, Fc, and F(ab’)2.
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- Briefly explain the characteristics of the Immunoglobulin (Ig) Classes.An injection contains 5 million international units (MIU) of interferon alpha-n3 (ALFERON N) proteins per milliliter. The recommended dose is 0.05 mL. The literature states that the activity of interferon alpha-n3 is approximately equal to 2.6 × 108international units/mg of protein. Calculate (a) the number of international units and (b) the micrograms of interferon alfa-n3 proteins administered per dose.With the aid of diagrams, discuss the role of autoantibodies in three named autoimmune diseases, then discuss how four named monoclonal antibody therapies (biologics) have been used to treat patients with autoimmunity in 2000 words.
- Identify three other methods commonly used to visualize lipids on a TLC plate. Specify the type or class of lipids that are detected using these methods.Please answer fastDescribe the difference between (A) ‘naked antibodies’ and (B) conjugated antibodies in the context of using humanized monoclonal antibodies for tumor killing.
- Describe the structure of immunoglobulin and the functions of the Fab and Fc portions..A table comparing the biological characteristics of the five classes of immunoglobulins is shown below. Answer yes or no in the spaces provided, (You can draw the table in your answer paper) IgE IgD Biological activity a) Activates classical complement pathway b) Present on the membrane of the mature B cells c) Present in secretions d) Induces mast-cell degranulation e) Crosses placenta IgG IgA IgMEach of the following statements concerning the macrophages is true, EXCEPT:* D Sometimes referred to Langerhans cells in the skin Contain numerous primary and secondary lysosomes Have variable shape, because they move in connective tissues O D Manufacture antibodies. O O Phagocytosis of bacteria