Which of the following is a major consequence of activation of phospholipase C-B (PLCB) by the Gq trimeric GTPase?OA. Elevation of intracellular CAMP levels, leading to the activation of protein kinase AOB. Elevation of PIP3 levels in the plasma membrane, leading to the activation of protein kinase BOC. Elevation of intracellular Ca2+ levels, leading to the activation of protein kinase CD. Elevation of IP3 in the plasma membrane, leading to the activation of protein kinase DOE. Elevation of intracellular cGMP levels, leading to the activation of protein kinase G

The correct answer is C. Elevation of intracellular Ca2+ levels, leading to the activation of…

Answered: Which of the following is a major…

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter9: Cell Communication

Section: Chapter Questions

Problem 1VCQ: Figure 9.8 HER2 is a receptor tyrosine kinase. In 30 percent of human breast cancers, HER2 is...

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Similar questions

In which of the following schematic drawings of signaling pathways does the activation of the receptor lead to gene expression? Activating and inhibitory steps are indicated with (+) and (-), respectively. OA OB ㅇㅂㅇㅂㅇㅁ (+) Gene Expression Activated Signaling proteins Transcription receptor activator Bl D Gene Expression Gene Expression ㅁㅁㅇ Gene Expression Gene Expression
What distinguishes a steroid receptor from a receptor tyrosine kinase receptor or a G-protein-coupled receptor?
Histamine binds to the H1 G-protein-linked receptor to initiate the itchiness and airway constriction associated with an allergic response. If a mutation in the associated G-protein’s alpha subunit prevented the hydrolysis of GTP how would the allergic response change? More severe allergic response compared to normal G-protein signaling. Less severe allergic response compared to normal G-protein signaling. No allergic response. No change compared to normal G-protein signaling.
Second-messenger systems ultimately bring about the desired cell response by inducing a change in the shape and function of particular designated intracellular proteins. (True or false?)
Outline the three general means by which binding of a water soluble extracellular chemical messenger to its matching surface membrane receptor brings about the desired intracellular response.
Calcium ions (a) can act as second messengers (b) split calmodulin (c) are kept at higher concentration in the cytosol than in the extracellular fluid (d) are produced in the ER by protein kinases and protein phosphatases (e) typically terminate signaling cascades
Which of the following is incorrect about pathways activated by G-proteincoupled receptors? a. The extracellular signaling molecule is the first messenger. b. When activated, plasma membrane-bound G protein canswitch on an effector. c. Second messengers enter the nucleus. d. ATP converts to cAMP to activate protein kinases. e. Protein kinases phosphorylate molecules to change cellularactivity.
Figure 37.5 Heat shock proteins (HSP) are so named because they help refold misfolded proteins. In response to increased temperature (a “heat shock"), heat shock proteins are activated by release from the NR/HSP complex. At the same time, transcription of HSP genes is activated. Why do you think the cell responds to a heat shock by increasing the activity of proteins that help refold misfolded proteins?
Discuss Concepts Describe the possible ways in which a G-proteincoupled receptor pathway could become defective and not trigger any cellular responses.
Trace the sequence of events in signal transduction for each of the following second messengers: cyclic AMP, inositol trisphosphate (IP3), diacylglycerol (DAG), and calcium ions.
Figure 9.10 In certain cancers, the GTPase activity of the RAS G-protein is inhibited. This means that the RAS protein can no longer hydrolyze GTP into GDP What effect would this have on downstream cellular events?
A common membrane-bound intermediary between the receptor and the effector protein within the plasma membrane is the __________________.

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