Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg rabbits following an oral Linuron dose of 400 mg/kg. Time (minutes) Serum Linuron Levels (ug/ml) following IV dose Serum Linuron Levels (ug/ml) following oral dose 5 1.71 10 15.48 2.00 15 2.11 20 8.60 1.75 30 5.90 1.26 45 3.78 0.92 60 2.42 0.72 90 1.49 0.51 120 0.93 0.41 180 0.60 0.34 240 0.41 0.28 300 0.29 0.24 360 0.22 0.20 420 0.17 480 0.14 Analyze this data and perform the necessary calculations to determine the following pharmacokinetic parameters from the oral Linuron data: (5 points per parameter, 23 parameters/variables = 115 points possible). You do NOT need to submit graphs or data tables. (The IV data is from HW4 but replicated here in case you didn't save your answers and need to redo part of it to determine the bioavailability).
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg rabbits following an oral Linuron dose of 400 mg/kg. Time (minutes) Serum Linuron Levels (ug/ml) following IV dose Serum Linuron Levels (ug/ml) following oral dose 5 1.71 10 15.48 2.00 15 2.11 20 8.60 1.75 30 5.90 1.26 45 3.78 0.92 60 2.42 0.72 90 1.49 0.51 120 0.93 0.41 180 0.60 0.34 240 0.41 0.28 300 0.29 0.24 360 0.22 0.20 420 0.17 480 0.14 Analyze this data and perform the necessary calculations to determine the following pharmacokinetic parameters from the oral Linuron data: (5 points per parameter, 23 parameters/variables = 115 points possible). You do NOT need to submit graphs or data tables. (The IV data is from HW4 but replicated here in case you didn't save your answers and need to redo part of it to determine the bioavailability).
Chapter9: Parenteral Medication Labels And Dosage Calculation
Section: Chapter Questions
Problem 6.4P
Related questions
Question
Give the terminal regression line equation and R or R2 value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the first residual regression line equation and R or R2 value:
Give the x axis (name and units, if any) of the first residual line
: Give the y axis (name and units, if any) of the first residual line:
Give the second residual regression line equation and R or R2 value:
Give the x axis (name and units, if any) of the second residual line:
Give the y axis (name and units, if any) of the second residual line:
- a) B1
Solution
- b) B2
c)hybrid rate constant (λ1)
d)hybrid rate constant (λ2)
- e) ka
- f) t1/2,absorb
- g) t1/2, dist
- h) t1/2, elim
i)apparent central compartment volume (V1,app)
- j) total AUC (short cut method)
- k) apparent volume of distribution based on AUC (VAUC,app)
l)apparent clearance (CLapp)
- m) absolute bioavailability of oral route (need AUCiv from 116ml)
Transcribed Image Text:Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg rabbits
following an oral Linuron dose of 400 mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
Serum Linuron Levels (ug/ml)
following oral dose
5
1.71
10
15.48
2.00
15
2.11
20
8.60
1.75
30
5.90
1.26
45
3.78
0.92
60
2.42
0.72
90
1.49
0.51
120
0.93
0.41
180
0.60
0.34
240
0.41
0.28
300
0.29
0.24
360
0.22
0.20
420
0.17
480
0.14
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the oral Linuron data: (5 points per parameter, 23 parameters/variables = 115
points possible). You do NOT need to submit graphs or data tables. (The IV data is from HW4 but
replicated here in case you didn't save your answers and need to redo part of it to determine the
bioavailability).
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