% Maximal response 100- m to 10 Agonist (log M) % Maximal response 100- m to 10 Agonist (log M)

Principles Of Pharmacology Med Assist
6th Edition
ISBN:9781337512442
Author:RICE
Publisher:RICE
Chapter27: Medications That Affect The Nervous System
Section: Chapter Questions
Problem 23RQ
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The following figure is from Caterina et al. The capsaicin receptor: a heat activated ion channel in the pain pathway. Nature, 1997. Black boxes indicate capsaicin, white circles indicate resinferatoxin. a) Which has a higher potency? b) Which is has a higher efficacy? c) What is the approximate Kd of capsaicin in uM? (you can round to the nearest power of 10)
% Maximal response
100-
m
to
10
Agonist (log M)
Transcribed Image Text:% Maximal response 100- m to 10 Agonist (log M)
% Maximal response
100-
m
to
10
Agonist (log M)
Transcribed Image Text:% Maximal response 100- m to 10 Agonist (log M)
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