Genetic Analysis: An Integrated Approach (2nd Edition)
2nd Edition
ISBN: 9780321948908
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 12, Problem 20P
Summary Introduction
To analyze:
Can the homologous recombination be considereda mutational event that resultsin gene conversion? Write justification for the answer.
Introduction:
Recombination is the exchange of DNA strands, in which new
In homologous recombination, nucleotide sequences are switched between two identical molecules of DNA.
Theunidirectional exchange of nucleotide sequences between similar sequences is gene conversion. In gene conversion, to repair one stretch of sequence, another stretch of arrangement is used as a model.
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Chapter 12 Solutions
Genetic Analysis: An Integrated Approach (2nd Edition)
Ch. 12 - 11.1 Identify two general ways chemical mutagens...Ch. 12 - 11.2 Nitrous acid and (BU) alter DNA by different...Ch. 12 - 11.19 Using the adeninethymine base pair in this...Ch. 12 - The partial amino acid sequence of a wild-type...Ch. 12 - 5. Thymine is usually in its normal, common form....Ch. 12 - Ultraviolet (UV) radiation is mutagenic.
What...Ch. 12 - Researchers interested in studying mutation and...Ch. 12 - The effect of base - pair substitution mutations...Ch. 12 - Prob. 9PCh. 12 - 11.10 In numerous population studies of...
Ch. 12 - 11.11 Two different mutations are identified in a...Ch. 12 - 11.22 Many human genes are known to have homologs...Ch. 12 - 11.13 Answer the following questions concerning...Ch. 12 - Prob. 14PCh. 12 - Prob. 15PCh. 12 - Prob. 16PCh. 12 - 11.15 A sample of the bacterium is exposed to...Ch. 12 - 11.16 A strain of is identified as having a null...Ch. 12 - Define gene conversion and contrast it with gene...Ch. 12 - Prob. 20PCh. 12 - Prob. 21PCh. 12 - Prob. 22PCh. 12 - Prob. 23PCh. 12 - Prob. 24PCh. 12 - 25. If homologous recombination did not occur,...Ch. 12 - In this chapter, three features of genes or of DNA...Ch. 12 - Briefly compare the production of DNA double -...Ch. 12 - During mismatch repair, why is it necessary to...Ch. 12 - 11.27 Following the spill of a mixture of...Ch. 12 - A geneticist searching for mutations uses the...Ch. 12 - A wild - type culture of haploid yeast is exposed...Ch. 12 - A fragment of a wild - type polypeptide is...Ch. 12 - Prob. 33PCh. 12 - 11.40 Common baker’s yeast () is normally grown at...Ch. 12 - 11.41 The two gels illustrated below contain...Ch. 12 - Alkaptonuria is a human autosomal recessive...Ch. 12 - 11.33 In an experiment employing the methods of...Ch. 12 - Using your knowledge of DNA repair pathways choose...Ch. 12 - 11.35 Ataxia telangiectasia is a human inherited...Ch. 12 - 40. Two haploid strains of fungus are fused to...
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- Describe two forms of genetic recombination. What functions do they fulfill?arrow_forwardA yeast strain with a mutant spo11- allele has been isolated. The mutant allele is nonfunctional; it makes no spo11 protein. What do you suppose is the phenotype of this mutant strain?arrow_forwardIn a transformation experiment involving a wild type bacterial strain with a recipient strain with mutations in genes f, g, h and i pairs of genes were analyzed for co-transformation with the following results: Gene Pair Co-transformation g+ i+ f+ i+ yes no f+ h+ Уes f+ g+ no g+ h+ h+ i+ no уes What is the linear order of these genes relative to cach other?arrow_forward
- Explain how exon shuffling can be due to unequal homologous recombination.arrow_forwardHydroxylamine (HA) causes only G • C → A • T transitions in DNA. Will HA produce nonsense mutations in wild-type strains?arrow_forwardThe work of McClintock showed that the presence of a transposoncan create a mutable site or locus that is subject to frequent chromosomebreakage. Why do you think a transposon creates a mutable site? If chromosome breakage occurs, do you think the transposon has moved somewhere else? How would you experimentally determine if it has?arrow_forward
- During light chain gene rearrangement, multiple V to J recombinations can occur. This cannot occur in heavy chain rearrangement because: 1. After the first heavy chain rearrangement the RAG complex is irreversibly turned off 2. There is only one J gene segment at the heavy chain locus 3. All the other V region genes are removed during the first recombination 4. All the intervening D segments are removed during the first recombinationarrow_forwardWhich of the following statements about linkage disequilibrium is false? a.) A new mutation first exists in a state of perfect, chromosome-wide linkage disequilibrium b.) Linkage disequilibrium is a statistical state detected when two loci segregate independently c.) Linkage disequilibrium is a transient state that can disappear with genetic recombination d.) Physical linkage is required for two loci to be in a state of linkage disequilibrium.arrow_forwardThe mutation for drug resistance in Mycobacterium tuberculosis, the bacteria that causes the disease tuberculosis, occurs within the chromosome, not in the plasmid. How do you think this would affect the likelihood of an individual bacterium becoming drug resistant?arrow_forward
- If homologous and site-specific recombination could not occur,what would be the harmful and the beneficial consequences?arrow_forwardIn DNA-hybridization experiments on six species of plants in the genus Vicia, DNA was isolated from each of the six species, denatured by heating, and sheared into small fragments (W. Y. Chooi. 1971. Genetics 68:213–230). In one experiment, DNA from each species and from E. coli was allowed to renature. The graph shows the results of this renaturation experiment. Q. Notice that, for the Vicia species, the rate of renaturation is much faster in the first hour and then slows down. What might cause this initial rapid renaturation and the subsequent slowdown?arrow_forwardIn the Holliday model for homologous recombination shown, the resolution steps can produce recombinant or nonrecombinantchromosomes. Explain how this can occur.arrow_forward
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genetic recombination strategies of bacteria CONJUGATION, TRANSDUCTION AND TRANSFORMATION; Author: Scientist Cindy;https://www.youtube.com/watch?v=_Va8FZJEl9A;License: Standard youtube license