Genetic Analysis: An Integrated Approach (2nd Edition)
2nd Edition
ISBN: 9780321948908
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Textbook Question
Chapter 12, Problem 6P
Ultraviolet (UV) radiation is mutagenic.
What kind of DNA lesion does UV energy cause?
How do UV
Identify and describe two DNA repair mechanism that remove UV
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Identify the various types of DNA repair mechanisms known to counteract the effects of UV radiation.
Drag the terms on the left to the appropriate blanks on the right to complete the sentences.
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SoS repair
is dependent on a photon-activated enzyme that cleaves thymine dimers.
excision repair
is the process by which an endonuclease clips out UV-induced dimers, DNA
photoreactivation repair
polymerase III fills in the gap, and DNA ligase rejoins the phosphodiester backbone.
recombinational repair
uses the corresponding region on the umdamaged parental strand of the same
polarity.
is a process in E. coli that induces error-prone DNA replication in an effort to fill
gaps by inserting random nucleotides.
Explain why base excision repair, nucleotide excision repair, and mismatch repair—which all require nucleases to excise damaged DNA—require DNA ligase.
There are two types of excision repair, base excision repair (BER) and nucleotide excision repair (NER).
Which enzymes are used in Base excision repair in E. coli?And In nucleotide excision repair, what kind of damage is repaired by this mechanism and why are cutsmade on both sides of the damaged region of DNA?
Chapter 12 Solutions
Genetic Analysis: An Integrated Approach (2nd Edition)
Ch. 12 - 11.1 Identify two general ways chemical mutagens...Ch. 12 - 11.2 Nitrous acid and (BU) alter DNA by different...Ch. 12 - 11.19 Using the adeninethymine base pair in this...Ch. 12 - The partial amino acid sequence of a wild-type...Ch. 12 - 5. Thymine is usually in its normal, common form....Ch. 12 - Ultraviolet (UV) radiation is mutagenic.
What...Ch. 12 - Researchers interested in studying mutation and...Ch. 12 - The effect of base - pair substitution mutations...Ch. 12 - Prob. 9PCh. 12 - 11.10 In numerous population studies of...
Ch. 12 - 11.11 Two different mutations are identified in a...Ch. 12 - 11.22 Many human genes are known to have homologs...Ch. 12 - 11.13 Answer the following questions concerning...Ch. 12 - Prob. 14PCh. 12 - Prob. 15PCh. 12 - Prob. 16PCh. 12 - 11.15 A sample of the bacterium is exposed to...Ch. 12 - 11.16 A strain of is identified as having a null...Ch. 12 - Define gene conversion and contrast it with gene...Ch. 12 - Prob. 20PCh. 12 - Prob. 21PCh. 12 - Prob. 22PCh. 12 - Prob. 23PCh. 12 - Prob. 24PCh. 12 - 25. If homologous recombination did not occur,...Ch. 12 - In this chapter, three features of genes or of DNA...Ch. 12 - Briefly compare the production of DNA double -...Ch. 12 - During mismatch repair, why is it necessary to...Ch. 12 - 11.27 Following the spill of a mixture of...Ch. 12 - A geneticist searching for mutations uses the...Ch. 12 - A wild - type culture of haploid yeast is exposed...Ch. 12 - A fragment of a wild - type polypeptide is...Ch. 12 - Prob. 33PCh. 12 - 11.40 Common baker’s yeast () is normally grown at...Ch. 12 - 11.41 The two gels illustrated below contain...Ch. 12 - Alkaptonuria is a human autosomal recessive...Ch. 12 - 11.33 In an experiment employing the methods of...Ch. 12 - Using your knowledge of DNA repair pathways choose...Ch. 12 - 11.35 Ataxia telangiectasia is a human inherited...Ch. 12 - 40. Two haploid strains of fungus are fused to...
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- Eukaryotes have repair systems that prevent mutations due to copying errors and exposure to mutagens. What are the three excision-repair systems found in eukaryotes, and which one is responsible for correcting thymine-thymine dimers that form as a result of UV light damage to DNA?arrow_forwardWhat is/are the attributes that make nucleotide excision repair (NER) and base excision repair (BER) similar and/or different from each other? Select the correct response: The NER pathway is the only one that can remove DNA lesions in the strand regardless of their size which is followed by attaching the correct strand, then sealed by a DNA ligase. They both use the enzyme DNA glycosylases that recognizes the damaged DNA segments and proceed with repairing the faulty base in the strand. They differ NER only repairs purine bases while BER repairs pyrimidine bases. They both remove the damaged parts of the DNA where the BER pathway corrects only the identified damaged bases which are usually non-bulky lesions. The NER pathway, on the other hand, repairs the damage by removal of bulky DNA adducts which is a short-single stranded DNA segment. They both utilize the enzyme photolyase to reverse the damages created by the faulty section of the DNA. They both remove the damaged parts of the…arrow_forwardDNA repair systems are responsible for maintaining genomic fidelity in normal cells despite the high frequency with which mutational events occur. What type of DNA mutation is generated by (a) UV radiation and (b) ionizing radiation? Describe the system responsible for repairing each of these types of mutations in mammalian cells. Postulate why a loss of function in one or more DNA repair systems typifies many cancers.arrow_forward
- What is the purpose of DNA methylation? Why is it ineffective in the DNA repair of spontaneous deamination of C? Explain in 4 to 6 sentences.arrow_forwardPlease explain one type of “DNA repair” mechanism (what is it, when is it used, how does it work).arrow_forwardWhy are X rays more potent mutagens than UV radiation?arrow_forward
- Although exposure to both types of radiation can cause DNA damage, ionizing radiation and UV affect DNA differently. Explain the differences in the types of mutation caused by these mutagens.arrow_forwardExtreme UV exposure leads to the SOS response in bacteria. By what mechanism does the SOS response function? Answer choices induction of photolyase and the addition of white light to remove the thymine dimer destruction of lexA, which leads to expression of an alternate, error-prone DNA polymerase homologous recombination repair non-homologous end joining exinuclease removal of a segment of DNA including a thymine dimer, followed by the replacement of DNA using the complementary strand of DNAarrow_forwardA pyrimidine dimer which is a bulky lesion has mutated an E. coli cell's DNA. Describe both the photoreactivation enzyme repair (PRE) and Nucleotide excision repair describe how the cell uses Uvr A, B, C, D gene products to effect repair.arrow_forward
- Which of the following statements regarding Nucleotide Excision Repair (NER) and Base Excision Repair (BER) is true? Only NER involves the action of DNA ligase to seal nicks in the DNA backbone. Both NER and BER involve DNA strand cleavage by an endonuclease. Both NER and BER can be activated by exposure to visible light. Only BER requires DNA polymerase. Both NER and BER involve the creation of an apyrimidinic (AP) site.arrow_forwardMatch the bold DNA repair response(s) to the triggering type of DNA damage. Homologous Recombination Mishmatch Repair Base Excision Repair Nucleotide Excision Repair Non-homologous End Joining Single-strand DNA breaks Removal of repair lesions such as photoproducts caused by UV including Thymine dimers Double-Strand Break repair mechanism which is an accurate repair mechanism without any introduction of insertions or deletions. It requires a sister chromatid as a template. This repair mechanism uses just DNA glycosylase to remove Uracil (no other enzymes or complexes are required) then DNA polymerase can use the template stand to add the complementary base where the Uracil has been removedInterstrand Crosslink Repair This repair mechanism is used to recognize and repair mis-incorporation of base that can arise during DNA replication. Removal and replacement of modifying bases such as Uracil, 8-hyroxyguanine and others. Double-strand Break that is termed as “Quick and Dirty” as it is…arrow_forwardExplain why the absorption of UV light by double-stranded DNA increases (the hyperchromic effect) when the DNA is denatured.arrow_forward
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