Biochemistry: The Molecular Basis of Life
6th Edition
ISBN: 9780190209896
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
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Chapter 12, Problem 10Q
Summary Introduction
To review:
The reason for the gallstone’s formation in obese patients.
Introduction:
The gallstone is a crystal composed of the cholesterol and the inorganic salts. It is a painful disorder and the factors responsible for it are obesity and the infection of the gallbladder. The cholesterol is a lipid molecule present in the membrane of cell and other body parts. It is insoluble in water and gets incorporated into micelles of bile salts and the phospholipids.
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The carbon-nitrogen peptide bond is rigid, but rotation can take place
about the bond between the nitrogen and a-carbon atoms and the bond
between the a-carbon and the carbonyl carbon atom. These bond angles
define the conformation of the peptide chain.
Consider the Ramachandran plot shown to answer both questions.
fr (degrees)
180
120
8280
60
°
-60
Which observation most likely describes part of an observed a helix?
p=-59 degrees; y = +150 degrees; many Ser residues
qp=-140 degrees; w +130 degrees; many Val residues
qp=-57 degrees; y = -47 degrees; many Pro residues
qp=-60 degrees; y = -47 degrees; many Ala residues
p = +60 degrees; y = +40 degrees; many Gly residues
Which observations would not likely occur in a ẞ sheet?
qp=-59 degrees; y = -49 degrees; many Ala residues
qp = +60 degrees; w = +60 degrees; many Gly residues
qp=-120 degrees; y = +120 degrees; many Tyr residues
☐ ☐
qp=-139 degrees; y = +135 degrees; many Val residues
op=-51 degrees; w+153 degrees; many Gly and Pro…
Please give an intuitive explanation of the difference, if any, between toxicokinetics and pharmacokinetics.
A protein biochemist attempted to determine the amino acid sequence of a decapeptide. The results from the trypsin,
chymotrypsin, and cyanogen bromide treatments are shown:
⚫ Trypsin digestion gave two fragments with multiple residues (not in order):
• T1: Ala, Arg, Phe, Gly, Thr, Trp, Tyr
o T2: Lys, Met, Val
Chymotrypsin digestion gave four fragments with multiple residues (not in order):
• CT1: Ala, Phe
• CT2: Thr, Trp
• CT3: Lys, Met, Tyr, Val
。 CT4: Arg, Gly
⚫ Treatment with cyanogen bromide yielded a single amino acid, methionine, and a nonapeptide.
What is a possible sequence of the decapeptide? Use three-letter abbreviations in your answer, and add a dash between
each residue.
Chapter 12 Solutions
Biochemistry: The Molecular Basis of Life
Ch. 12 - Prob. 1QCh. 12 - Prob. 2QCh. 12 - Prob. 3QCh. 12 - Prob. 4QCh. 12 - Prob. 5QCh. 12 - Prob. 6QCh. 12 - Prob. 7QCh. 12 - Prob. 8QCh. 12 - Prob. 9QCh. 12 - Prob. 10Q
Ch. 12 - Prob. 1RQCh. 12 - Prob. 2RQCh. 12 - Prob. 3RQCh. 12 - Prob. 4RQCh. 12 - Prob. 5RQCh. 12 - Prob. 6RQCh. 12 - Prob. 7RQCh. 12 - Prob. 8RQCh. 12 - Prob. 9RQCh. 12 - Prob. 10RQCh. 12 - Prob. 11RQCh. 12 - Prob. 12RQCh. 12 - Prob. 13RQCh. 12 - Prob. 14RQCh. 12 - Prob. 15RQCh. 12 - Prob. 16RQCh. 12 - Prob. 17RQCh. 12 - Prob. 18RQCh. 12 - Prob. 19RQCh. 12 - Prob. 20RQCh. 12 - Prob. 21RQCh. 12 - Prob. 22RQCh. 12 - Prob. 23RQCh. 12 - Prob. 24RQCh. 12 - Prob. 25RQCh. 12 - Prob. 26RQCh. 12 - Prob. 27RQCh. 12 - Prob. 28RQCh. 12 - Prob. 29RQCh. 12 - Prob. 30RQCh. 12 - Prob. 31RQCh. 12 - Prob. 32RQCh. 12 - Prob. 33RQCh. 12 - Prob. 34RQCh. 12 - Prob. 35RQCh. 12 - Prob. 36RQCh. 12 - Prob. 37RQCh. 12 - Prob. 38RQCh. 12 - Prob. 39RQCh. 12 - Prob. 40RQCh. 12 - Prob. 41RQCh. 12 - Prob. 42RQCh. 12 - Prob. 43RQCh. 12 - Prob. 44RQCh. 12 - Prob. 45RQCh. 12 - Prob. 46FBCh. 12 - Prob. 47FBCh. 12 - Prob. 48FBCh. 12 - Prob. 49FBCh. 12 - Prob. 50FBCh. 12 - Prob. 51FBCh. 12 - Prob. 52FBCh. 12 - Prob. 53FBCh. 12 - Prob. 54FBCh. 12 - Prob. 55FBCh. 12 - Prob. 56SACh. 12 - Prob. 57SACh. 12 - Prob. 58SACh. 12 - Prob. 59SACh. 12 - Prob. 60SACh. 12 - Prob. 61TQCh. 12 - Prob. 62TQCh. 12 - Prob. 64TQCh. 12 - Prob. 65TQCh. 12 - Prob. 66TQCh. 12 - Prob. 67TQCh. 12 - Prob. 68TQCh. 12 - Prob. 71TQCh. 12 - Prob. 72TQ
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