Biochemistry: The Molecular Basis of Life
6th Edition
ISBN: 9780190209896
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
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Chapter 12, Problem 57SA
Summary Introduction
To review:
Conjugation reactions underwent by bile acids and their physiological significance.
Introduction:
Bile acids are steroid acids, which are synthesized by the liver from cholesterol. It is secreted in the bile juice and emulsifies dietary fatty acids and helps in their digestion. Examples include deoxycholic acidand cholic acids.
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Four distinct classes of interactions (inter and intramolecular forces) contribute to a protein's tertiary and quaternary structures. Name the interaction then describe the amino acids that can form this type of interaction. Draw and annotate a diagram of the interaction between two amino acids.
Examine the metabolic pathway. The enzymes that catalyze each step are identified as "e" with a numeric subscript.
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Which enzymes catalyze irreversible reactions?
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Which of the enzymes is likely to be the allosteric
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An allosteric enzyme that follows the concerted model has an allosteric coefficient (T/R) of 300 in the absence of substrate.
Suppose that a mutation reversed the ratio.
Select the effects this mutation will have on the relationship between the rate of the reaction (V) and substrate
concentration, [S].
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The enzyme would likely follow Michaelis-Menten kinetics.
The plot of V versus [S] would be sigmoidal.
The enzyme would mostly be in the T form.
The plot of V versus [S] would be hyperbolic.
The enzyme would be more active.
Chapter 12 Solutions
Biochemistry: The Molecular Basis of Life
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