Use this mRNA coding sequence as your starting point. This sequence begins with a start codon and ends with a stop codon, so it is only looking at the region of DNA that directly encodes a protein sequence. 5’-AUGCACAAAUUAGAGUACCCCCCAGGAAGGUAG-3’ Make the following mutation in this sequence by changing/adding/removing only one nucleotide. Make the mutation easy to see (a different color, circled, something like that) A frameshift mutation

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Use this mRNA coding sequence as your starting point. This sequence begins with a start codon and ends with a stop codon, so it is only looking at the region of DNA that directly encodes a protein sequence.

5’-AUGCACAAAUUAGAGUACCCCCCAGGAAGGUAG-3’

Make the following mutation in this sequence by changing/adding/removing only one nucleotide. Make the mutation easy to see (a different color, circled, something like that)

A frameshift mutation

**Table 13.1: The Genetic Code**

This table explains the genetic code using three-letter codons, specifying which amino acids are produced from combinations of nucleotides. The chart is organized into a grid that aids in decoding the codons.

### Structure of the Table:

- **Rows and Columns:**
  - The horizontal rows indicate the first base in the codon (U, C, A, G).
  - The vertical columns indicate the second base in the codon (U, C, A, G).
  - Each cell within the table lists the possible third base options and the corresponding amino acid or function.

### Explanation of the Grid:

#### **First Base: U**
- **UUU, UUC**: Phenylalanine (Phe)
- **UUA, UUG**: Leucine (Leu)
- **UCU, UCC, UCA, UCG**: Serine (Ser)
- **UAU, UAC**: Tyrosine (Tyr)
- **UAA, UAG**: Stop codon
- **UGU, UGC**: Cysteine (Cys)
- **UGA**: Stop codon
- **UGG**: Tryptophan (Trp)

#### **First Base: C**
- **CUU, CUC, CUA, CUG**: Leucine (Leu)
- **CCU, CCC, CCA, CCG**: Proline (Pro)
- **CAU, CAC**: Histidine (His)
- **CAA, CAG**: Glutamine (Gln)
- **CGU, CGC, CGA, CGG**: Arginine (Arg)

#### **First Base: A**
- **AUU, AUC, AUA**: Isoleucine (Ile)
- **AUG**: Methionine (Met); start codon
- **ACU, ACC, ACA, ACG**: Threonine (Thr)
- **AAU, AAC**: Asparagine (Asn)
- **AAA, AAG**: Lysine (Lys)
- **AGU, AGC**: Serine (Ser)
- **AGA, AGG**: Arginine (Arg)

#### **First Base: G**
- **GUU, GUC, GUA, GUG
Transcribed Image Text:**Table 13.1: The Genetic Code** This table explains the genetic code using three-letter codons, specifying which amino acids are produced from combinations of nucleotides. The chart is organized into a grid that aids in decoding the codons. ### Structure of the Table: - **Rows and Columns:** - The horizontal rows indicate the first base in the codon (U, C, A, G). - The vertical columns indicate the second base in the codon (U, C, A, G). - Each cell within the table lists the possible third base options and the corresponding amino acid or function. ### Explanation of the Grid: #### **First Base: U** - **UUU, UUC**: Phenylalanine (Phe) - **UUA, UUG**: Leucine (Leu) - **UCU, UCC, UCA, UCG**: Serine (Ser) - **UAU, UAC**: Tyrosine (Tyr) - **UAA, UAG**: Stop codon - **UGU, UGC**: Cysteine (Cys) - **UGA**: Stop codon - **UGG**: Tryptophan (Trp) #### **First Base: C** - **CUU, CUC, CUA, CUG**: Leucine (Leu) - **CCU, CCC, CCA, CCG**: Proline (Pro) - **CAU, CAC**: Histidine (His) - **CAA, CAG**: Glutamine (Gln) - **CGU, CGC, CGA, CGG**: Arginine (Arg) #### **First Base: A** - **AUU, AUC, AUA**: Isoleucine (Ile) - **AUG**: Methionine (Met); start codon - **ACU, ACC, ACA, ACG**: Threonine (Thr) - **AAU, AAC**: Asparagine (Asn) - **AAA, AAG**: Lysine (Lys) - **AGU, AGC**: Serine (Ser) - **AGA, AGG**: Arginine (Arg) #### **First Base: G** - **GUU, GUC, GUA, GUG
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