All of the following statements regarding immunoglobulin gene rearrangement are true except a. Non-B cells retain their chromatin containing the immunoglobulin loci in a ‘closed’ configuration. b. T-cells never transcribe immunoglobulin genes. c. There is only one promoter on the heavy-chain locus that is 5ʹ of the V segments. d. Pax-5, a transcription factor, interacts with enhancer sequences positioned 3ʹ of the heavy-chain C-region genes. e. Transcription of immunoglobulin loci precedes gene rearrangement.

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A: Let's begin with examining the terms in the question.

Immunology

Immunology is the division of science involved with the immune reactions occurring in living organisms. The organisms are accustomed to evolving internal defense mechanisms to evade the invasion of microbial pathogens. Diverse cells are connected with stimulating the immune responses, which produce inhospitable conditions to the microbes prompting their lysis and thus inhibits the multiplication of the pathogens. The immune system can distinguish the pathogens through the aid of cellular intercommunication and launch responses to destroy them.