A unclecapeptide (11 amino acias) was Isolated from a soll microbe cincl subjected to proteolytic digestion and cycnogen bromide cleavage. Results from experiment below: Chymotrypsin treatment produced 3 fragments with the following sequence: met-Pro-G714-Tur LYS-LYS-Leu AICI - ASP - ASP-Phe •Tripsin treatment produced, Augment AKA-ASP-CISP-phe-met-pro-gly-Tur-Lys cyanogen bomide produced 2 fragments. The fragment not bearing the nomoserine lactone was found to have the following sequence: Pro-Gly-Tur-LYS-LYS-Leu

Curren'S Math For Meds: Dosages & Sol
11th Edition
ISBN:9781305143531
Author:CURREN
Publisher:CURREN
Chapter10: Reconstitution Of Powdered Drugs
Section: Chapter Questions
Problem 4.2P
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What is the primary sequence of this undecapeptide? Also,   if x-ray crystallography shows a highly stable hairpin turn within the polypeptide, what about the primary sequence explains this structural feature?

A unclecapeptide (11 amino acias) was
Isolated from a soll microbe cincl subjected
to proteolytic digestion and cycnogen
bromide cleavage. Results from
experiment below:
Chymotrypsin treatment produced
3 fragments with the following
sequence:
met-Pro-G714-Tur
LYS-LYS-Leu
AICI - ASP - ASP-Phe
•Tripsin treatment produced, Augment
AKA-ASP-CISP-phe-met-pro-gly-Tur-Lys
cyanogen bomide produced 2 fragments.
The fragment not bearing the nomoserine
lactone was found to have the
following sequence:
Pro-Gly-Tur-LYS-LYS-Leu
Transcribed Image Text:A unclecapeptide (11 amino acias) was Isolated from a soll microbe cincl subjected to proteolytic digestion and cycnogen bromide cleavage. Results from experiment below: Chymotrypsin treatment produced 3 fragments with the following sequence: met-Pro-G714-Tur LYS-LYS-Leu AICI - ASP - ASP-Phe •Tripsin treatment produced, Augment AKA-ASP-CISP-phe-met-pro-gly-Tur-Lys cyanogen bomide produced 2 fragments. The fragment not bearing the nomoserine lactone was found to have the following sequence: Pro-Gly-Tur-LYS-LYS-Leu
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