Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN: 9781305251052
Author: Michael Cummings
Publisher: Cengage Learning
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Chapter 16, Problem 13QP
The prospect of using gene therapy to alleviate genetic conditions is still a vision of the future. Gene therapy for adenosine deaminase deficiency has proved to be quite promising, but many obstacles remain to be overcome. Currently, the correction of human genetic defects is done using retroviruses as vectors. For this purpose, viral genes are removed from the retroviral genome, creating a vector capable of transferring human structural genes into sites on human chromosomes within target-tissue cells. Do you see any potential problems with inserting pieces of a retroviral genome into humans? If so, are there ways to combat or prevent these problems?
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Chapter 16 Solutions
Human Heredity: Principles and Issues (MindTap Course List)
Ch. 16.5 - Should fertility clinics be required to disclose...Ch. 16.5 - Prob. 2EGCh. 16 - Would ISCI be an option? Why or why not? Jan, a...Ch. 16 - Jan is concerned about using ART. She wants to be...Ch. 16 - List the common infertility problems in women....Ch. 16 - Prob. 2QPCh. 16 - Prob. 3QPCh. 16 - What is the difference between gamete...Ch. 16 - Why should women consider collecting and freezing...Ch. 16 - Prob. 6QP
Ch. 16 - Researchers are learning how to transfer...Ch. 16 - Prob. 8QPCh. 16 - Cystic fibrosis is an autosomal disease that...Ch. 16 - Prob. 10QPCh. 16 - Gene therapy involves: a. the introduction of...Ch. 16 - In selecting target cells to receive a transferred...Ch. 16 - The prospect of using gene therapy to alleviate...Ch. 16 - Is gene transfer a form of eugenics? Is it...Ch. 16 - A couple who wishes to have children visits you, a...Ch. 16 - A couple has had a child born with...Ch. 16 - You are a genetic counselor, and your patient has...Ch. 16 - Prob. 18QP
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Retroviruses may transform cells in more than one way. From the figure given below, explain the two ways by which cells are transformed. You have the purified protein overexpressed in the cell. How will you determine which pathway of expression is occurring in the cell? Promoter V-onc Retroviral DNA - Retroviral DNA Retroviral Proto- promoter oncogene Proto- V-onc oncogene Host cell DNA - Host cell DNA Excessive Lexpression Expression C-onc V-onc MRNA W MRNA Abnormal protein (hyperactive) Protein product Abnormal cell growtharrow_forwardIn the treatment of acquired immunodeficiency syndrome (AIDS), a possible mode of therapy is to inhibit the reverse transcriptase (RT) of the human immunodeficiency virus (HIV), whcih is required for the retrovirus to be propogated by RNA-directed DNA synthesis. In the figure below, one of the substrates for RT is thymidine; and two drugs, AZT and HBY097 are known to inhibit HIV RT> (a) Thymidine; (b) AZT; (c) HBY097 Look at the structures and predict the type of inhibition (i.e. competitive or non-competitive) likely to be shown by each drug. By using knowledge on enzyme, plan an experiment that would enable you to confirm the type of inhibition by investigating enzyme kinetics and explain how you would interpret the results.Remarks: Not more than 250 words.arrow_forwardIn recombinant DNA technology, vectors are used to transfer a gene of interest in the host cells. Mention any three features of vectors that are most suitable for this purpose.arrow_forward
- Explain how viral vectors can be used for gene therapy, and provide two examples of commonly used viral vectors. What are some of the major challenges that must be overcome to develop safer and more effective viral vectors for gene therapy?arrow_forwardGive 4 examples of transcription factors / non-structural proteins you have learned in this course? Identify the most commonly used technique for diagnosing COVID-19? And the clinical sample for each technique. …….…… virus can cause encephalitis, cancer, sexually transmitted disease, infect external genitalia, mucosal surfaces, gladiatorum, and/or other diseases. How can the infection with this virus be avoided? Suggest two ways of prevention or to destroy the virus.arrow_forwardOne of the reasons why phage therapy has not been applied widely is that bacteria can become resistant to bacteriophages as well, through mutations in genes encoding for specific proteins. What would be a protein in the bacterial cell that, if mutated, would make that cell resistant to phage infection?arrow_forward
- Please help me answer all parts of this question: (A)What strategy/type of vaccine would you pursue with the hopes of developing a vaccine to a new pandemic Coronavirus, attenuated virus vaccine or an inactivated virus vaccine? Compare how the two are produced, the limitations or advantages, and justify why you have picked one over the other. (B) Now, compare the above vaccines to mRNA vaccines. How are mRNA vaccines delivered? Are they better than the vaccines from part (A)?arrow_forwardWhile a stem cell transplant from an unaffected donor is currently the only cure for DBA, genome-editing technologies may one day enable the correction of a mutation in a patient’s own bone marrow stem cells. However, what specific information would be needed, beyond a symptom-based diagnosis of DBA, in order to accomplish this?arrow_forwardWhich of the following conditions is most likely to be successfully treated by gene therapy using a viral vector to deliver a wild-type copy of one gene that is present in mutant form in a person with the condition? Assume that the viral vector used has the ability to home to relevant target tissues. Also assume that the patient can be treated at a young enough age to avoid irreversible phenotypic impacts of the mutation described. Timothy Syndrome, a multi-system disorder characterized by dysmorphic features and autistic behavioral traits, caused by overexpression of calcium channel gene Cerebral adrenoleukodystrophy (ALD), a neurological disorder caused by a frameshift mutation knocking out the function of the ABCD1 gene encoding a lipid transporter Osteogenesis imperfecta caused by a dominant negative mutation in the collagen A1 gene Myopia (shortsightedness), a vision impairment with heritability estimates in the range of 0.6-0.8, where risk is impacted by at least 200 genesarrow_forward
- How does one performs a Southern blot and how one performs a western blot? Then, consider what a Southern blot can detect, and what a western blot can detect. Finally, connect a specific biological mechanism for how viruses can cause cancer to each of the two pieces of data that you have.arrow_forwardTwo approaches for correcting single-gene defects are gene therapy such as is discussed in Section 3-5D and the CRISPR–Cas9 system. Explain why the CRISPR–Cas9 approach can potentially provide more complete restoration of normal tissue function than gene therapy.arrow_forwardHow would you determine if a transfection was transient or stable? This image might be helpfularrow_forward
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