Human Heredity: Principles and Issues (MindTap Course List)
Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN: 9781305251052
Author: Michael Cummings
Publisher: Cengage Learning
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Chapter 16, Problem 7QP

Researchers are learning how to transfer sperm-making cells from fertile male mice into infertile male mice in the hopes of learning more about reproductive abnormalities. These donor spermatogonia cells have developed into mature spermatozoa in 70% of cases, and some recipients have gone on to father pups (as baby mice are called). This new advance opens the way for a host of experimental genetic manipulations. It also offers enormous potential for correcting human genetic disease. One potentially useful human application of this procedure is treating infertile males who wish to be fathers.

  1. a. Do you foresee any ethical or legal problems with the implementation of this technique? If so, elaborate on the concerns.
  2. b. Could this procedure have the potential for misuse? If so, explain how.
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A couple has a young child who needs a bone marrow transplant.  They propose that preimplantation screening be done on several embryos fertilized in vitro to find a match for their child.  What do they need to match in this transplant procedure?  The couple proposes that the matching embryo be transplanted to the mother’s uterus and serves as a bone marrow donor when old enough.  What are the ethical issues (if any) involved in this proposal?
Preimplantation genetic testing for aneuploidy (PGT-A) is meant to identify and discard embryos with chromosome number abnormalities.  However, it has not been proven to be valuable in human IVF.  What do you think PGT-A is not working as expected
Is it acceptable or not to edit the genome of human embryos to treat genetic diseases?   There is a group of genetic disorders that cause fatal childhood diseases. To avoid having children with these genetic disorders, some parents choose to use a procedure called in vitro fertilization (IVF) followed by genetic testing. Typically, in the first step of IVF, women receive hormone injections to produce multiple eggs, after which the eggs are harvested. The eggs are then fertilized by sperm in a petri dish to make embryos, which are then transferred to a woman's uterus. If the goal is to identify embryos that do not have specific genetic conditions, doctors would screen the embryos before they are implanted into the woman - in other words, they would analyze the embryos' DNA to look for variants of the gene(s) that cause the genetic disorder. While the genetic testing of IVF-produced embryos has been done for decades, the procedure is controversial. The controversies include worries that…
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The Human Reproductive System; Author: Professor Dave Explains;https://www.youtube.com/watch?v=TucxiIB76bo;License: Standard YouTube License, CC-BY