Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN: 9781305251052
Author: Michael Cummings
Publisher: Cengage Learning
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Chapter 16, Problem 9QP
Cystic fibrosis is an autosomal disease that mainly affects the white population, and 1 in 20 whites are heterozygotes. Genetic testing can diagnose heterozygotes. Should a genetic screening program for cystic fibrosis be instituted? Should the federal government fund it? Should the program be voluntary or mandatory, and why?
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Cystic Fibrosis (CF) is an autosomal recessive condition. Therefore, heterozygous (Cc) carriers do not display symptoms. Two parents who are carriers plan to start a family and you are a genetic counselor helping to advise them about their chances of having children affected by CF.
a) Suppose the couple has 4 children, each one year apart. What is the probability that all 4 children will inherit CF?
b) What is the probability that any 3 of their 4 children will not inherit CF, but 1 will be affected?
c) What is the probability that their first child will not inherit CF, but the younger 3 children will inherit CF?
Cystic fibrosis (CF) is an autosomal recessive trait. A three-generation pedigree is shown below for a family that carries the mutant allele for cystic fibrosis. Note that carriers are not colored in to allow you to figure out their genotypes. Normal allele = F CF mutant allele = f
What is the genotype of individual #13?
A) ff
B) FF
C) Ff
D) it is impossible to tell
Cystic fibrosis is an autosomal recessive disorder that affects 1 in 3 000 newborns with Caucasian background. It causes thick mucus build up in various organs and can cause damages and problems in respiratory and digestive systems.
a) What is the frequency of the cystic fibrosis allele in the Caucasian population? Show all your work and express your answer as a value between 0 and 1 rounded to two decimal places.
b) What percentage of the Caucasian population would be carriers for cystic fibrosis? Show all your work and express your answer rounded to two decimal places.
c)If two individuals are carriers of the cystic fibrosis allele, what is the probability that they would have a girl without cystic fibrosis? Show all your work (including the Punnett square) and express your answer as a value between 0 and 1 rounded to two decimal places.
Chapter 16 Solutions
Human Heredity: Principles and Issues (MindTap Course List)
Ch. 16.5 - Should fertility clinics be required to disclose...Ch. 16.5 - Prob. 2EGCh. 16 - Would ISCI be an option? Why or why not? Jan, a...Ch. 16 - Jan is concerned about using ART. She wants to be...Ch. 16 - List the common infertility problems in women....Ch. 16 - Prob. 2QPCh. 16 - Prob. 3QPCh. 16 - What is the difference between gamete...Ch. 16 - Why should women consider collecting and freezing...Ch. 16 - Prob. 6QP
Ch. 16 - Researchers are learning how to transfer...Ch. 16 - Prob. 8QPCh. 16 - Cystic fibrosis is an autosomal disease that...Ch. 16 - Prob. 10QPCh. 16 - Gene therapy involves: a. the introduction of...Ch. 16 - In selecting target cells to receive a transferred...Ch. 16 - The prospect of using gene therapy to alleviate...Ch. 16 - Is gene transfer a form of eugenics? Is it...Ch. 16 - A couple who wishes to have children visits you, a...Ch. 16 - A couple has had a child born with...Ch. 16 - You are a genetic counselor, and your patient has...Ch. 16 - Prob. 18QP
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- Cystic fibrosis in humans is caused by a recessive allele. A man is known to be a carrier of the cystic fibrosis allele. He marries a phenotypically normal woman. In the general population, the incidence of cystic fibrosis at birth is approximately 1 in 1,700. Assume Hardy-Weinberg proportions. What is the probability that the wife is also a carrier? Answer in decimal number only (three decimal places; example: 0.123). What is the probability that their first child will be affected? Answer in decimal number only (three decimal places; example: 0.123).arrow_forwardDuchenne muscular dystrophy is sex linked and usually affects only males. Victims of the disease become progressively weaker, starting early in life.a. What is the probability that a woman whose brother has Duchenne’s disease will have an affected child?b. If your mother’s brother (your uncle) had Duchenne’s disease, what is the probability that you have received the allele?c. If your father’s brother had the disease, what is the probability that you have received the allele?arrow_forwardEpilepsy is a central nervous system (neurological) disorder in which brain activity becomes abnormal, causing seizures or periods of unusual behavior, sensations and sometimes loss of awareness. For epilepsy, the concordance values are 72% for monozygotic twins and 15% for dizygotic twins. 1) Is this a single gene inheritance or multifactorial disease? 2) Is there a strong genetic or environmental cause to the development of this disease? If both genetic and environmental causes are implicated, you have to indicate each of them separately.arrow_forward
- Albinism is a recessive disorder where there is a lack of melanin. Andrea and her husband Claude both have normal skin pigmentation. Andrea’s mother has the albino phenotype, but her father and her brother do not (normal pigmentation). Claude’s parents are both normal, but he has a sister who has the condition (is albino). Answer the following questions If Andrea and Claude are carriers for the albino allele, what is the probability that they have an albino child? If Andrea and Claude have a second child, what is the probability this child be normal (non-albino)? NOTE: Draw a punnet square or show your work.arrow_forwardAlbinism is an autosomal (not sex-linked) recessive trait. A man and woman are both of normal pigmentation and have one child out of three who is albino (without melanin pigmentation). What are the genotypes of the albino's parents? Both parents must be homozygous dominant. Both parents must be heterozygous. One parent must be homozygous dominant; the other parent must be heterozygous. One parent must be heterozygous; the other parent can be homozygous dominant, homozygous recessive, or heterozygous. One parent must be homozygous for the recessive allele; the other parent can be homozygous dominant, homozygous recessive, or heterozygous. O O O O Oarrow_forwardHuntington's Chorea is an autosomal dominant trait. Below is a pedigree of a family with Huntington's disease. If III-6 had a child with a healthy individual, what would be the chance they would have a child with Huntington's? Group of answer choices a 100% b 25% c 50% d 0%arrow_forward
- Cystic fibrosis is a disease that is passed down through the generations. The recessive alleles for cystic fibrosis are heterozygous carriers in both parents. What is the probability that one of their children may develop cystic fibrosis?arrow_forwardHere is one question with two sub-questions. Thank you for your time.arrow_forwardYOUR SISTER DIED FROM TAY-SACHS DISEASE, INHERITED AS A RECESSIVE ALLELE (t). you're married and planning to start your family. you're worried about the disease and decide to have genetic testing to see if you or your spouse is a carrier of the tay-sachs allele. the test results show that you're a carrier of the allele, but your spouse isn't. what is the probability that you and your spouse will have a child with tay-sachs disease? show your work.arrow_forward
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