I'm struggling with this topic and would really appreciate your help. I need to hand-draw a diagram and explain the process of sexual differentiation in humans, including structures, hormones, enzymes, and other details. Could you also make sure to include these terms in the explanation? . Gonads . Wolffian ducts • Müllerian ducts . ⚫ Testes . Testosterone • Anti-Müllerian Hormone (AMH) . Epididymis • Vas deferens ⚫ Seminal vesicles ⚫ 5-alpha reductase ⚫ DHT - Penis . Scrotum . Ovaries • Uterus ⚫ Fallopian tubes - Vagina - Clitoris . Labia Thank you so much for your help!
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- As outlined in this chapter, sex can be defined at several levels: chromosomal, gonadal, and phenotypic. To this we can add psychological sex, the sex one believes themselves to be. Determining someones sex is a complex issue that is often difficult to resolve, as the case of Bruce Reimer (see Section 7.1) illustrates. In spite of the complexity surrounding this issue, the International Olympic Committee (IOC) and the International Association of Athletics Federations (IAFF) still use sex testing on female athletes to determine whether they can compete in athletic events as females. This has led to serious personal, social, and legal issues, and the practice has been widely condemned and widely defended. Lets examine two such cases here. An Indian athlete, Santhi Soundarajan, finished second in the 800-meter run at the Asian Games in Doha, Qatar, in 2006. After the race, she was asked to take a sex test. According to press reports, the tests showed that she appeared to have abnormal chromosomes. An official stated that she had more Y chromosomes than allowed. As a result, she was stripped of her medal, banned from further competition by the Indian Olympic Association, and shunned by her local community. Before the race in Doha, Santhi had competed in 8 international competitions and won 12 medals. Sometime after this incident, she attempted suicide. She now runs a training school for athletes in Tamil Nadu, India. Although the number and types of tests done on Santhi have not been revealed, such tests usually involve examination of the external genitals, a chromosome analysis, and measurement of hormone levels. Suppose you were on the committee deciding whether Santhi could compete as a female. Consider each of the following hypothetical tests one at a time and base your conclusions only on the results of that test. The results of a physical examination show she has female genitals. On this basis, would you allow her to keep her medal and compete as a female in future races? Suppose the results of a chromosomal analysis shows that she has an XY chromosome set and is chromosomally male. Would you allow her to keep her medal and compete as a female? Lastly, suppose a test for hormone levels shows that she has levels of the male sex hormone testosterone that are higher than average for females but at least 10 times lower than the average for males. Would you allow her to keep her medal and compete in future races as a female? Now, put the results of all three tests together, and consider them as a whole. What are your conclusions? Now, lets consider the case of a South African runner, Caster Semenya, who won the 800-meter run at the World Championships held in Berlin, Germany, in 2009. After the race, she was asked to undergo sex testing. The IAAF stated that the tests were requested to ascertain whether she had a rare medical condition that gave her an unfair physical advantage. The nature of the tests and their results were not released, but press reports indicate that she did not have ovaries or a uterus, and had testosterone levels intermediate between the averages for males and females. In the end, the IAAF agreed to keep the results of her tests confidential, and Caster was allowed to keep her medal and return to international competition in 2010. In both cases, what the IAAF considers the threshold for determining who can compete as a female has not been stated. Would you recommend that testing of female athletes be continued to ensure that males do not compete as females? Or should all such testing be banned?As outlined in this chapter, sex can be defined at several levels: chromosomal, gonadal, and phenotypic. To this we can add psychological sex, the sex one believes themselves to be. Determining someones sex is a complex issue that is often difficult to resolve, as the case of Bruce Reimer (see Section 7.1) illustrates. In spite of the complexity surrounding this issue, the International Olympic Committee (IOC) and the International Association of Athletics Federations (IAFF) still use sex testing on female athletes to determine whether they can compete in athletic events as females. This has led to serious personal, social, and legal issues, and the practice has been widely condemned and widely defended. Lets examine two such cases here. An Indian athlete, Santhi Soundarajan, finished second in the 800-meter run at the Asian Games in Doha, Qatar, in 2006. After the race, she was asked to take a sex test. According to press reports, the tests showed that she appeared to have abnormal chromosomes. An official stated that she had more Y chromosomes than allowed. As a result, she was stripped of her medal, banned from further competition by the Indian Olympic Association, and shunned by her local community. Before the race in Doha, Santhi had competed in 8 international competitions and won 12 medals. Sometime after this incident, she attempted suicide. She now runs a training school for athletes in Tamil Nadu, India. Although the number and types of tests done on Santhi have not been revealed, such tests usually involve examination of the external genitals, a chromosome analysis, and measurement of hormone levels. Suppose you were on the committee deciding whether Santhi could compete as a female. Consider each of the following hypothetical tests one at a time and base your conclusions only on the results of that test. The results of a physical examination show she has female genitals. On this basis, would you allow her to keep her medal and compete as a female in future races? Suppose the results of a chromosomal analysis shows that she has an XY chromosome set and is chromosomally male. Would you allow her to keep her medal and compete as a female? Lastly, suppose a test for hormone levels shows that she has levels of the male sex hormone testosterone that are higher than average for females but at least 10 times lower than the average for males. Would you allow her to keep her medal and compete in future races as a female? Now, put the results of all three tests together, and consider them as a whole. What are your conclusions? Now, lets consider the case of a South African runner, Caster Semenya, who won the 800-meter run at the World Championships held in Berlin, Germany, in 2009. After the race, she was asked to undergo sex testing. The IAAF stated that the tests were requested to ascertain whether she had a rare medical condition that gave her an unfair physical advantage. The nature of the tests and their results were not released, but press reports indicate that she did not have ovaries or a uterus, and had testosterone levels intermediate between the averages for males and females. In the end, the IAAF agreed to keep the results of her tests confidential, and Caster was allowed to keep her medal and return to international competition in 2010. In both cases, what the IAAF considers the threshold for determining who can compete as a female has not been stated. Based on what is known about the test results in this case and the hypothetical tests in the first case, do you think the outcome in each case was fair?Figure 43.15 Which of the following statements about hormone regulation of the female reproductive cycle is false? LH and FSH are produced in the pituitary, and estradiol and progesterone are produced in the ovaries. Estradiol and progesterone secreted from the corpus luteum cause the endometrium to thicken. Both progesterone and estradiol are produced by the follicles. Secretion of GnRH by the hypothalamus is inhibited by low levels of estradiol but stimulated by high levels of estradiol.
- Figure 43.17 Which of the following statements about the menstrual cycle is false? Progesterone levels rise during the luteal phase of the ovarian cycle and the secretory phase of the uterine cycle. Menstruation occurs just after LH and FSH levels peak. Menstruation occurs after progesterone levels drop. Estrogen levels rise before ovulation, while progesterone levels rise after.How Is Sex Determined? The absence of a Y chromosome in an early embryo causes the: a. embryonic testis to become an ovary b. Wolffian duct system to develop c. Mllerian duct system to degenerate d. indifferent gonad to become an ovary e. indifferent gonad to become a testisWould ISCI be an option? Why or why not? Jan, a 32-year-old woman, and her husband, Darryl, have been married for 7 years. They have attempted to have a baby on several occasions. Five years ago, they had a first-trimester miscarriage, followed by an ectopic pregnancy later the same year. Jan continued to see her OB/GYN physician for infertility problems but was very dissatisfied with the response. After four miscarriages, she went to see a fertility specialist, who diagnosed her with severe endometriosis and polycystic ovarian disease (detected by hormone studies). The infertility physician explained that these two conditions were hampering her ability to become pregnant and thus making her infertile. She referred Jan to a genetic counselor. At the appointment, the counselor explained to Jan that one form of endometriosis (MIM 131200) can be a genetic disorder, and that polycystic ovarian disease can also be a genetic disorder (MIM 184700) and is one of the most common reproductive disorders among women. The counselor recommended that a detailed family history of both Jan and Darryl would help establish whether Jans problems have a genetic component and whether any of her potential daughters would be at risk for one or both of these disorders. In the meantime, Jan is taking hormones, and she and Darryl are considering alternative modes of reproduction. Using the information in Figure 16.4, explain the reproductive options that are open to Jan and Darryl.
- Figure 18.17 Which of the following statements about hormone regulation of the female reproductive cycle is false? a. LH and FSH are produced in the pituitary, and estrogen and progesterone are produced in the ovaries. b. Estradiol and progesterone secreted from the corpus luteum cause the endometrium to thicken. c. Both progesterone and estrogen are produced by the follicles. d. Secretion of GnRH by the hypothalamus is inhibited by low levels of estrogen but stimulated by high levels of estrogen.Figure 43.8 Which of the following statements about the male reproductive system is false? The vas deferens carries sperm from the testes to the penis. Sperm mature in seminiferous tubules in the testes. Both the prostate and the bulbourethral glands produce components of the semen. The prostate gland is located in the testes.In order for sexual intercourse to produce a pregnancy, both partners must experience _____. a. orgasm b. ejaculation c. affection d. none of the above
- Outline the roles of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in the ovarian cycle of a human female.Ovulation releases _________. a. the corpus luteum b. a primordial follicle c. a primary oocyte d. a secondary oocyte and first polar bodyOne of your best friends tells you that she and her husband think she might be pregnant. She feels she can wait until shes several months along before finding an obstetrician. You think she could use some medical advice sooner, and you suggest she discuss her plans with a physician as soon as possible. What kinds of health issues might you be concerned about?
